Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | PI4KA | P42356 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11307193 | 0.84 | NPC1 (0.51) | NPC1PKMRAB9APIK3CDPIK3CA | |
| SCHEMBL11265691 | 0.83 | TLR8 (0.39) | NPC1PKMRAB9ATLR9TLR8 | |
| SCHEMBL11274521 | 0.82 | NPC1 (0.49) | NPC1PKMRAB9APIK3CDPIK3CA | |
| SCHEMBL11262069 | 0.82 | DYRK1A (0.44) | TLR9TLR8TLR7 | |
| SCHEMBL11256701 | 0.79 | KDM4E (0.52) | NPC1RAB9APIK3CDPIK3CAPI4KA | |
| SCHEMBL11271590 | 0.78 | NPC1 (0.46) | NPC1PKMRAB9APIK3CDPIK3CA | |
| SCHEMBL11256912 | 0.76 | POLB (0.51) | NPC1PKMRAB9APIK3CDPIK3CA | |
| SCHEMBL10705931 | 0.76 | DYRK3 (0.46) | NPC1RAB9APIK3CAPI4KAPI4KB | |
| SCHEMBL21663423 | 0.75 | CYP1A2 (0.35) | NPC1PKMRAB9AMAPT | |
| SCHEMBL11269149 | 0.74 | PDE3B (0.49) | PIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0055453-A2 | 5-(Pyridinyl)-benzimidazole derivatives and preparation | STERLING DRUG INC. (US) | 1982-07-07 | — | — | EP | disclosed |
| US-4335132-A | 5-(Py-Y)-1H-benzimidazol-2-ols and 5-(Py-Y-)-1H-benzimidazole-2-thiols | STERLING DRUG, INC. (US) | 1982-06-15 | — | — | US | disclosed |