Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 5/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.49 |
| ▸ | CLK1 | P49759 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | RHEB | Q15382 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.41 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11266981 | 0.89 | SCD (0.45) | PDE3BPDE3ACLK1JAK2KDM4E | |
| SCHEMBL10705931 | 0.84 | DYRK3 (0.46) | CLK1JAK2KDM4EPIK3CAMKNK1 | |
| SCHEMBL11262069 | 0.81 | DYRK1A (0.44) | — | |
| SCHEMBL11256701 | 0.81 | KDM4E (0.52) | JAK2KDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL11260816 | 0.79 | PDE3B (0.49) | PDE3BPDE3ACLK1JAK2KDM4E | |
| SCHEMBL16848371 | 0.79 | JAK2 (0.50) | PDE3BPDE3ACLK1JAK2KDM4E | |
| SCHEMBL17493786 | 0.79 | PDE3B (0.49) | PDE3BPDE3ACLK1JAK2KDM4E | |
| SCHEMBL11221691 | 0.79 | PDE3B (0.49) | PDE3BPDE3ACLK1JAK2KDM4E | |
| Ridinilazole SCHEMBL413723 | 0.79 | ALDH1A1 (0.66) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| Ridinilazole SCHEMBL29379856 | 0.79 | ALDH1A1 (0.66) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0055453-A2 | 5-(Pyridinyl)-benzimidazole derivatives and preparation | STERLING DRUG INC. (US) | 1982-07-07 | — | — | EP | claimed |
| US-4335132-A | 5-(Py-Y)-1H-benzimidazol-2-ols and 5-(Py-Y-)-1H-benzimidazole-2-thiols | STERLING DRUG, INC. (US) | 1982-06-15 | — | — | US | claimed |
| EP-0055453-A2 | 5-(Pyridinyl)-benzimidazole derivatives and preparation | STERLING DRUG INC. (US) | 1982-07-07 | — | — | EP | disclosed |
| US-4335132-A | 5-(Py-Y)-1H-benzimidazol-2-ols and 5-(Py-Y-)-1H-benzimidazole-2-thiols | STERLING DRUG, INC. (US) | 1982-06-15 | — | — | US | disclosed |