Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 11/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 11/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 7/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | GCGR | P47871 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11265691 | 0.86 | TLR8 (0.39) | DYRK1ATLR8TLR7TLR9 | |
| SCHEMBL11261025 | 0.82 | ABL1 (0.44) | DYRK1AABL1TLR8TLR7TLR9 | |
| SCHEMBL11260933 | 0.82 | NPC1 (0.49) | TLR8TLR7TLR9 | |
| SCHEMBL11262645 | 0.81 | SREBF2 (0.41) | ABL1TLR7TLR9MAP4K4CDC7 | |
| SCHEMBL11269149 | 0.81 | PDE3B (0.49) | — | |
| SCHEMBL11299685 | 0.79 | DDAH1 (0.47) | DYRK1AABL1TLR8TLR7TLR9 | |
| SCHEMBL11275736 | 0.78 | ABL1 (0.45) | DYRK1AABL1TLR8TLR7TLR9 | |
| SCHEMBL11272286 | 0.78 | PRKCI (0.36) | TLR8TLR7TLR9GSK3B | |
| SCHEMBL10705931 | 0.76 | DYRK3 (0.46) | DYRK1AGSK3BCLK4 | |
| SCHEMBL21812326 | 0.75 | CDK5 (0.42) | DYRK1AABL1TLR8TLR7TLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0055453-A2 | 5-(Pyridinyl)-benzimidazole derivatives and preparation | STERLING DRUG INC. (US) | 1982-07-07 | — | — | EP | disclosed |
| US-4335132-A | 5-(Py-Y)-1H-benzimidazol-2-ols and 5-(Py-Y-)-1H-benzimidazole-2-thiols | STERLING DRUG, INC. (US) | 1982-06-15 | — | — | US | disclosed |