Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11250255 | 0.90 | KDM4E (0.39) | KDM4EMAPTPOLBMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11250253 | 0.90 | KDM4E (0.39) | KDM4EMAPTPOLBMEN1KMT2A | |
| SCHEMBL11369725 | 0.79 | SMN1; SMN2 (0.42) | KDM4EMAPTPOLBMEN1KMT2A | |
| SCHEMBL11369727 | 0.79 | SMN1; SMN2 (0.42) | KDM4EMAPTPOLBMEN1KMT2A | |
| SCHEMBL11367036 | 0.78 | KDM4E (0.40) | KDM4EMAPTPOLBMEN1KMT2A | |
| SCHEMBL11090997 | 0.76 | KDM4E (0.47) | KDM4EMAPTPOLBMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11089322 | 0.75 | KDM4E (0.46) | KDM4EMAPTPOLBMEN1KMT2A | |
| SCHEMBL11108580 | 0.74 | KDM4E (0.42) | KDM4EMAPTPOLBMEN1KMT2A | |
| SCHEMBL11100821 | 0.74 | KDM4E (0.43) | KDM4EMAPTPOLBMEN1KMT2A | |
| SCHEMBL11090768 | 0.73 | PDE4B (0.43) | KDM4EMAPTPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4321377-A | ANALGESICS, TRANQULIZERS, ANTIARTHERISOSCLEROTIC AGENTS | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) | 1982-03-23 | — | — | US | disclosed |