Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11050040 | 0.79 | MEN1 (0.40) | POLBMEN1KMT2AGAALMNA | |
| SCHEMBL11652626 | 0.79 | MEN1 (0.40) | POLBMEN1KMT2AGAALMNA | |
| SCHEMBL11650834 | 0.77 | GRIN2D (0.62) | POLBGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL11650836 | 0.77 | GRIN2D (0.62) | POLBGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL4109683 | 0.72 | GRIN2D (0.67) | POLBGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL4100972 | 0.71 | POLB (0.47) | POLBGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL11280869 | 0.70 | POLB (0.84) | POLBDRD2HTR2AHTR2BL3MBTL1 | |
| SCHEMBL11272202 | 0.70 | POLB (0.55) | POLBGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL11272212 | 0.70 | POLB (0.55) | POLBGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL11280882 | 0.70 | POLB (0.84) | POLBDRD2HTR2AHTR2BL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4326074-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4115564-A | Treatment of diarrhea with amidinoureas | WILLIAM H. RORER, INC. (US) | 1978-09-19 | — | — | US | disclosed |
| US-4025652-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1977-05-24 | — | — | US | disclosed |