Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11272212 | 1.00 | POLB (0.55) | POLBDRD2HTR2AHTR2BPKM | |
| SCHEMBL11287194 | 0.81 | POLB (0.42) | POLBDRD2HTR2AHTR2BPKM | |
| SCHEMBL11280869 | 0.81 | POLB (0.84) | POLBDRD2HTR2AHTR2BPKM | |
| SCHEMBL11280882 | 0.81 | POLB (0.84) | POLBDRD2HTR2AHTR2BPKM | |
| SCHEMBL11284346 | 0.80 | POLB (0.47) | POLBDRD2HTR2AHTR2BPKM | |
| Hydrochloric Acid SCHEMBL11562609 | 0.79 | POLB (0.82) | POLBDRD2HTR2AHTR2BPKM | |
| SCHEMBL11251266 | 0.79 | ALDH1A1 (0.44) | POLBDRD2HTR2AHTR2BPKM | |
| Hydrochloric Acid SCHEMBL11255459 | 0.77 | ALDH1A1 (0.43) | POLBDRD2HTR2AHTR2BPKM | |
| SCHEMBL11138510 | 0.77 | LMNA (0.45) | POLBALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL8873938 | 0.76 | ALDH1A1 (0.48) | POLBDRD2HTR2AHTR2BPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4326075-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4203920-A | ANTIDIARRHEAL | WILLIAM H. RORER, INC. (US) | 1980-05-20 | — | — | US | disclosed |
| US-4060635-A | Amidinoureas for treating diarrhea | WILLIAM H. RORER, INC. (US) | 1977-11-29 | — | — | US | disclosed |