Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.38 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28435242 | 0.82 | MAPT (0.52) | GAAPOLBALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL11254783 | 0.77 | MEN1 (0.43) | GAAPOLBALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL11254969 | 0.77 | SMN1; SMN2 (0.48) | GAAPOLBALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL8268871 | 0.74 | MAPT (0.47) | GAAPOLBALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL11254789 | 0.74 | MEN1 (0.40) | GAAPOLBALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL11254998 | 0.73 | MEN1 (0.49) | GAAALDH1A1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL31231118 | 0.73 | GAA (0.56) | GAAPOLBALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL30686655 | 0.73 | GAA (0.56) | GAAPOLBALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6949718 | 0.73 | GAA (0.56) | GAAPOLBALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL28444974 | 0.72 | DPP4 (0.42) | GAAPOLBALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4349675-A | 4,4-Disubstituted spiro-1,4-dihydropyridines and a process for their production | BAYER AKTIENGESELLSCHAFT (DE) | 1982-09-14 | — | — | US | disclosed |