Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.36 |
| ▸ | GRK6 | P43250 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.34 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CTSV | O60911 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11254783 | 0.96 | MEN1 (0.43) | MEN1KMT2ASMN1; SMN2MAPTGAA | |
| SCHEMBL11254998 | 0.81 | MEN1 (0.49) | MEN1KMT2ASMN1; SMN2MAPTGAA | |
| SCHEMBL10732486 | 0.79 | MAPT (0.45) | MEN1KMT2ASMN1; SMN2MAPTGAA | |
| SCHEMBL11039837 | 0.79 | LMNA (0.36) | MEN1KMT2ASMN1; SMN2MAPTHTT | |
| SCHEMBL6956520 | 0.78 | ALDH1A1 (0.64) | MEN1KMT2ASMN1; SMN2MAPTGAA | |
| SCHEMBL4384277 | 0.78 | ALDH1A1 (0.64) | MEN1KMT2ASMN1; SMN2MAPTGAA | |
| SCHEMBL10727028 | 0.78 | GRK6 (0.52) | MEN1KMT2ASMN1; SMN2MAPTGAA | |
| SCHEMBL11254969 | 0.76 | SMN1; SMN2 (0.48) | MEN1KMT2ASMN1; SMN2MAPTGAA | |
| SCHEMBL29383650 | 0.74 | KMT2A (0.49) | MEN1KMT2ASMN1; SMN2MAPTGAA | |
| SCHEMBL2636596 | 0.74 | KMT2A (0.49) | MEN1KMT2ASMN1; SMN2MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4349675-A | 4,4-Disubstituted spiro-1,4-dihydropyridines and a process for their production | BAYER AKTIENGESELLSCHAFT (DE) | 1982-09-14 | — | — | US | disclosed |