Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11263538 | 1.00 | ACE (0.39) | ACETSHRMEN1HPGDKMT2A | |
| SCHEMBL11267155 | 0.80 | ACE (0.39) | ACE | |
| SCHEMBL11267152 | 0.80 | ACE (0.39) | ACE | |
| SCHEMBL11259700 | 0.77 | ACE (0.41) | ACE | |
| SCHEMBL11164005 | 0.77 | ACE (0.46) | ACE | |
| SCHEMBL11215621 | 0.75 | ACE (0.50) | ACEKMT2A | |
| SCHEMBL7380820 | 0.75 | ACE (0.54) | ACE | |
| Water SCHEMBL5570208 | 0.74 | ACE (0.52) | ACE | |
| SCHEMBL11272121 | 0.73 | ACE (0.43) | ACE | |
| SCHEMBL11271111 | 0.73 | ACE (0.68) | ACEKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4330548-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1982-05-18 | — | — | US | disclosed |
| US-4296113-A | FOR TREATING HYPERTENSION BY INHIBITING ANGIOTENSIN CONVERTING ENZYME | E. R. SQUIBB & SONS, INC. (US) | 1981-10-20 | — | — | US | disclosed |