Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.35 |
| ▸ | PREP | P48147 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11215621 | 0.92 | ACE (0.50) | ACEPOLB | |
| SCHEMBL11259700 | 0.83 | ACE (0.41) | ACEPOLB | |
| SCHEMBL11263453 | 0.80 | ACE (0.41) | ACEPOLB | |
| SCHEMBL11272976 | 0.79 | ACE (0.49) | ACEHDAC3HDAC1HDAC10HDAC11 | |
| SCHEMBL11261402 | 0.78 | ACE (0.45) | ACE | |
| SCHEMBL11265881 | 0.75 | ACE (0.58) | ACE | |
| SCHEMBL16967407 | 0.75 | ACE (0.54) | ACE | |
| Water SCHEMBL5570206 | 0.74 | ACE (0.52) | ACE | |
| SCHEMBL11268004 | 0.74 | ACE (0.53) | ACE | |
| SCHEMBL11210160 | 0.74 | ACE (0.37) | ACEHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4330548-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1982-05-18 | — | — | US | disclosed |
| US-4296113-A | FOR TREATING HYPERTENSION BY INHIBITING ANGIOTENSIN CONVERTING ENZYME | E. R. SQUIBB & SONS, INC. (US) | 1981-10-20 | — | — | US | disclosed |