SCHEMBL11264089

SCHEMBL11264089

COc1ccc(CSCC(=O)NO)cc1

nearest known ligand 0.66

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.64
MAPT P10636 2/20 0.61
ALDH1A1 P00352 5/20 0.56
SMN1; SMN2 Q16637 4/20 0.55
LMNA P02545 3/20 0.55
KDM4E B2RXH2 1/20 0.55
RAB9A P51151 1/20 0.55
KMT2A Q03164 1/20 0.54
PKM P14618 1/20 0.52
ATM Q13315 1/20 0.52
HTT P42858 1/20 0.51
MMP1 P03956 1/20 0.50
TP53 P04637 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5410393 0.85 GAA (0.61) GAAMAPTALDH1A1SMN1; SMN2LMNA
SCHEMBL498480 0.81 CYP1A2 (0.67) GAAMAPTALDH1A1SMN1; SMN2LMNA
SCHEMBL11197684 0.81 MEN1 (0.61) GAAMAPTALDH1A1SMN1; SMN2LMNA
SCHEMBL7334996 0.81 GAA (0.57) GAAMAPTALDH1A1SMN1; SMN2LMNA
SCHEMBL17045933 0.81 HDAC1 (0.59) ALDH1A1SMN1; SMN2PKMMMP1
SCHEMBL11264491 0.80 SMN1; SMN2 (0.60) MAPTALDH1A1SMN1; SMN2LMNAKMT2A
SCHEMBL27629950 0.80 GAA (0.56) GAAMAPTALDH1A1SMN1; SMN2LMNA
SCHEMBL6084829 0.79 GAA (0.55) GAAMAPTALDH1A1SMN1; SMN2LMNA
SCHEMBL11272203 0.78 ALDH1A1 (0.60) GAAMAPTALDH1A1SMN1; SMN2LMNA
SCHEMBL11273795 0.78 KMT2A (0.71) MAPTALDH1A1SMN1; SMN2LMNARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4325964-A SEDATIVES, MUSCLE RELAXANTS, HYPOTENSIVE AGENTS LABORATOIRE L. LAFON (FR) 1982-04-20 US claimed
US-4325964-A SEDATIVES, MUSCLE RELAXANTS, HYPOTENSIVE AGENTS LABORATOIRE L. LAFON (FR) 1982-04-20 US disclosed
US-4225617-A PSYCHOTROPIC AGENTS LABORATOIRE L. LAFON (FR) 1980-09-30 US disclosed
US-4209524-A CENTRAL NERVOUS SYSTEM LABORATOIRE L. LAFON (FR) 1980-06-24 US disclosed
US-4209523-A TREATMENT OF THE CENTRAL NERVOUS SYSTEM LABORATOIRE L. LAFON (FR) 1980-06-24 US disclosed
US-4183951-A PSYCHOTROPIC AGENTS LABORATOIRE L. LAFON (FR) 1980-01-15 US disclosed
US-4152458-A CENTRAL NERVOUS SYSTEM, PSYCHOTROPIC AGENTS LABORATOIRE L. LAFON (FR) 1979-05-01 US disclosed
US-4151300-A CENTRAL NERVOUS SYSTEM, PSYCHOTROPIC LABORATOIRE L. LAFON (FR) 1979-04-24 US disclosed
US-4122186-A PSYCHOTROPIC AGENTS LABORATOIRE L. LAFON (FR) 1978-10-24 US disclosed