SCHEMBL11264491

SCHEMBL11264491

COc1ccc(CSCC(=O)NO)cc1OC

nearest known ligand 0.60

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 4/20 0.60
LMNA P02545 3/20 0.60
ALDH1A1 P00352 3/20 0.56
KMT2A Q03164 3/20 0.55
MEN1 O00255 2/20 0.55
HDAC3 O15379 1/20 0.52
HDAC1 Q13547 1/20 0.52
HDAC2 Q92769 1/20 0.52
HDAC8 Q9BY41 1/20 0.52
HSD17B10 Q99714 1/20 0.51
MAPT P10636 3/20 0.49
MAPK1 P28482 1/20 0.49
LDHA P00338 1/20 0.48
EPHX2 P34913 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11269213 0.86 SMN1; SMN2 (0.57) SMN1; SMN2LMNAALDH1A1KMT2AMEN1
SCHEMBL11265685 0.83 CYP1A2 (0.61) SMN1; SMN2LMNAALDH1A1KMT2AMEN1
SCHEMBL11264089 0.80 GAA (0.64) SMN1; SMN2LMNAALDH1A1KMT2AMAPT
SCHEMBL21156696 0.80 EPHX2 (0.64) SMN1; SMN2LMNAALDH1A1KMT2AHDAC3
SCHEMBL2420183 0.79 CA2 (0.65) ALDH1A1MAPTLDHA
SCHEMBL11414289 0.77 HDAC1 (0.65) ALDH1A1KMT2AMEN1HDAC3HDAC1
SCHEMBL11414291 0.75 HDAC1 (0.67) SMN1; SMN2LMNAALDH1A1KMT2AMEN1
SCHEMBL11269139 0.74 LMNA (0.56) SMN1; SMN2LMNAALDH1A1KMT2AMEN1
SCHEMBL27118038 0.73 CYP1A2 (0.57) SMN1; SMN2LMNAALDH1A1KMT2AMEN1
SCHEMBL198282 0.73 ALDH1A1 (0.62) SMN1; SMN2LMNAALDH1A1KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4325964-A SEDATIVES, MUSCLE RELAXANTS, HYPOTENSIVE AGENTS LABORATOIRE L. LAFON (FR) 1982-04-20 US claimed
US-4325964-A SEDATIVES, MUSCLE RELAXANTS, HYPOTENSIVE AGENTS LABORATOIRE L. LAFON (FR) 1982-04-20 US disclosed
US-4225617-A PSYCHOTROPIC AGENTS LABORATOIRE L. LAFON (FR) 1980-09-30 US disclosed
US-4209524-A CENTRAL NERVOUS SYSTEM LABORATOIRE L. LAFON (FR) 1980-06-24 US disclosed
US-4209523-A TREATMENT OF THE CENTRAL NERVOUS SYSTEM LABORATOIRE L. LAFON (FR) 1980-06-24 US disclosed
US-4183951-A PSYCHOTROPIC AGENTS LABORATOIRE L. LAFON (FR) 1980-01-15 US disclosed
US-4152458-A CENTRAL NERVOUS SYSTEM, PSYCHOTROPIC AGENTS LABORATOIRE L. LAFON (FR) 1979-05-01 US disclosed
US-4151300-A CENTRAL NERVOUS SYSTEM, PSYCHOTROPIC LABORATOIRE L. LAFON (FR) 1979-04-24 US disclosed
US-4122186-A PSYCHOTROPIC AGENTS LABORATOIRE L. LAFON (FR) 1978-10-24 US disclosed