Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11251240 | 0.90 | KMT2A (0.39) | MAPTGAATRPV1ALDH1A1NPC1 | |
| SCHEMBL7061962 | 0.81 | TP53 (0.42) | MAPTGAATRPV1ALDH1A1NPC1 | |
| SCHEMBL9052329 | 0.77 | MMP8 (0.50) | MAPTGAATRPV1ALDH1A1NPC1 | |
| SCHEMBL9515045 | 0.77 | GAA (0.38) | MAPTGAATRPV1ALDH1A1NPC1 | |
| SCHEMBL9515051 | 0.77 | GAA (0.38) | MAPTGAATRPV1ALDH1A1NPC1 | |
| SCHEMBL28825411 | 0.76 | MAPT (0.44) | MAPTGAATRPV1ALDH1A1NPC1 | |
| SCHEMBL16322386 | 0.76 | PSEN1 (0.49) | MAPTGAATRPV1ALDH1A1NPC1 | |
| SCHEMBL28964384 | 0.75 | HTT (0.41) | MAPTGAATRPV1ALDH1A1NPC1 | |
| SCHEMBL6788771 | 0.75 | MAPT (0.43) | MAPTGAATRPV1ALDH1A1NPC1 | |
| SCHEMBL7100159 | 0.75 | HTT (0.43) | MAPTGAATRPV1ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4360520-A | 1,4-Dihydropyridazine compounds, and their medicinal use | BAYER AKTIENGESELLSCHAFT (DE) | 1982-11-23 | — | — | US | disclosed |