Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.61 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.61 |
| ▸ | RAF1 | P04049 | 1/20 | 0.61 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.61 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.61 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10992179 | 0.84 | MAPK14 (0.83) | MAPK14MAPK13RAF1MAPK9MAPK12 | |
| Hydrochloric Acid SCHEMBL30023185 | 0.82 | MAPK14 (0.80) | MAPK14MAPK13RAF1MAPK9MAPK12 | |
| SCHEMBL7087770 | 0.77 | MAPK14 (0.67) | MAPK14MAPK13RAF1MAPK9MAPK12 | |
| SCHEMBL4434902 | 0.76 | MAPK14 (1.00) | MAPK14MAPK13RAF1MAPK9MAPK12 | |
| SCHEMBL6423292 | 0.76 | MAPK14 (1.00) | MAPK14MAPK13RAF1MAPK9MAPK12 | |
| SCHEMBL1173733 | 0.76 | MAPT (0.58) | MAPK14MAPK13RAF1MAPK9MAPK12 | |
| SCHEMBL1547683 | 0.75 | NQO1 (0.74) | KDM4EMAPTALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL5698694 | 0.73 | MAPK14 (0.61) | MAPK14MAPK13RAF1MAPK9MAPK12 | |
| Ammonia Solution, Strong SCHEMBL322908 | 0.73 | NQO1 (0.70) | KDM4ECACNA2D1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL11273419 | 0.72 | LMNA (0.52) | MAPK14MAPK13MAPK9MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0008755-B1 | ANTIINFLAMMATORY 4,5-DIARYL-2-NITROIMIDAZOLES, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-04-21 | — | — | EP | disclosed |
| US-4199592-A | Antiinflammatory 4,5-diaryl-2-nitroimidazoles | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1980-04-22 | — | — | US | disclosed |
| EP-0008755-A1 | Antiinflammatory 4,5-diaryl-2-nitroimidazoles, method for their preparation and pharmaceutical composition containing them | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1980-03-19 | — | — | EP | disclosed |