Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.53 |
| ▸ | IDO1 | P14902 | 4/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.51 |
| ▸ | RAF1 | P04049 | 1/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Imidazole SCHEMBL8030609 | 0.87 | MAPK14 (0.48) | MAPTKDM4ECYP3A4ADORA3IDO1 | |
| SCHEMBL9744537 | 0.83 | IDO1 (0.43) | MAPTKDM4ECYP3A4ADORA3IDO1 | |
| SCHEMBL10959629 | 0.80 | PDE10A (0.59) | MAPTKDM4ECYP3A4ADORA3IDO1 | |
| SCHEMBL24278328 | 0.79 | MAPT (0.51) | MAPTKDM4ECYP3A4ADORA3IDO1 | |
| SCHEMBL11834419 | 0.79 | KDM4E (0.64) | MAPTKDM4ECYP3A4ADORA3IDO1 | |
| SCHEMBL15664736 | 0.77 | IDO1 (0.46) | MAPTKDM4ECYP3A4IDO1MAPK13 | |
| SCHEMBL30014823 | 0.76 | IDO1 (0.56) | MAPTKDM4ECYP3A4IDO1MAPK13 | |
| SCHEMBL10355401 | 0.76 | SMN1; SMN2 (0.40) | MAPTKDM4EADORA3IDO1KMT2A | |
| SCHEMBL11265026 | 0.76 | MAPK14 (0.61) | MAPTKDM4ECYP3A4IDO1MAPK13 | |
| SCHEMBL10989572 | 0.76 | KDM4E (0.60) | MAPTKDM4ECYP3A4IDO1MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117946203-A | Glycyrrhetinic acid-gold complex and preparation method and application thereof | 南京中医药大学 | 2024-04-30 | — | — | CN | claimed |
| CN-117946203-A | Glycyrrhetinic acid-gold complex and preparation method and application thereof | 南京中医药大学 | 2024-04-30 | — | — | CN | disclosed |
| CN-110551156-B | Specific group-modified N1, N3-substituted 4,5-diaryl imidazole ring carbene rhodium complex and preparation method and application thereof | 南京中医药大学 | 2022-11-25 | — | — | CN | disclosed |
| US-7888118-B2 | induces differentiation of myoblasts or muscle fiber into neuron cells; drug screening; useful for treatment of neurodegenerative disorders, such as stroke, spinal cord injury, Parkinson's and Alzheimer's diseases; 2-{2-[5-(3-chlorophenyl)]furanyl}-4,5-bis(4-methoxyphenyl)imidazole (Neurodazine 1) | INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (KR) | 2011-02-15 | — | — | US | disclosed |
| US-20100184097-A1 | 4,5-BIS(4-METHOXYPHENYL)IMIDAZOLE COMPOUND INDUCING DIFFERENTIATION OF MYOBLASTS OR MUSCLE FIBERS INTO NEURON CELLS, A PHARMACEUTICAL COMPOSITION INCLUDING SAID COMPOUND, A METHOD OF INDUCING NEURON CELLS DIFFERENTIATION AND A SCREENING METHOD FOR IDENTIFYING ADDITIONAL COMPOUND USEFUL FOR INDUCING NEURON CELLS DIFFERENTIATION | INDUSTRY-ACADEMIC CORPORATION FOUNDATION, YONSEI UNIVERSITY (KR) | 2010-07-22 | — | — | US | disclosed |
| US-7718685-B2 | 4,5-bis(4-methoxyphenyl)imidizole compound inducing differentiation of myoblasts or muscle fibers and pharmaceutical compositions including said compound | INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (KR) | 2010-05-18 | — | — | US | disclosed |
| US-7718685-B2 | 4,5-bis(4-methoxyphenyl)imidizole compound inducing differentiation of myoblasts or muscle fibers and pharmaceutical compositions including said compound | INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (KR) | 2010-05-18 | — | — | US | disclosed |
| US-20050276764-A1 | Topical use of bis-arylimidazo[1,2-a]thiolane derivatives | BEIERSDORF AG | 2005-12-15 | — | — | US | disclosed |
| WO-2000019994-A9 | ESTROGEN RECEPTOR LIGANDS | UNIV ILLINOIS (US) | 2000-08-31 | — | — | WO | disclosed |
| EP-0626969-B1 | CoA-IT AND PAF INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2000-05-24 | — | — | EP | disclosed |
| US-4431722-A | POLYCYCLIC QUINONE PIGMENT DISPERSED IN A RESIN BINDER AS CHARGE GENERATING LAYER; ANTIFOGGING AGENTS | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1984-02-14 | — | — | US | disclosed |
| US-4402960-A | Antiinflammatory imidazole derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 1983-09-06 | — | — | US | disclosed |
| EP-0010361-B1 | BIS-IMIDAZOLES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BECKMAN CORPORATION (US) | 1983-04-27 | — | — | EP | disclosed |
| US-4372964-A | ANAGESIC, ANTIARTHRITIC | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1983-02-08 | — | — | US | disclosed |
| EP-0011115-B1 | ANTIINFLAMMATORY 2-SUBSTITUTED-1H-PHENANTHRO(9,10-D)IMIDAZOLES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-01-20 | — | — | EP | disclosed |
| EP-0043788-A1 | Imidazole derivatives, process for their preparation and their pharmaceutical compositions | SCHERING AKTIENGESELLSCHAFT (DE) | 1982-01-13 | — | — | EP | disclosed |
| EP-0032113-A2 | Antiinflammatory 4,5-diaryl-alpha-(polyhaloalkyl)-1H-imidazole-2-methanols | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-07-15 | — | — | EP | disclosed |
| US-4215135-A | Antiinflammatory 2-substituted-1H-phenanthro[9,10-d]imidazoles | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1980-07-29 | — | — | US | disclosed |
| EP-0011115-A1 | Antiinflammatory 2-substituted-1H-phenanthro(9,10-d)imidazoles, their preparation and pharmaceutical compositions containing them | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1980-05-28 | — | — | EP | disclosed |
| EP-0010361-A1 | Bis-imidazoles, their preparation and pharmaceutical compositions containing them | SMITHKLINE BECKMAN CORPORATION (US) | 1980-04-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100184097-A1 | 4,5-BIS(4-METHOXYPHENYL)IMIDAZOLE COMPOUND INDUCING DIFFERENTIATION OF MYOBLASTS OR MUSCLE FIBERS INTO NEURON CELLS, A PHARMACEUTICAL COMPOSITION INCLUDING SAID COMPOUND, A METHOD OF INDUCING NEURON CELLS DIFFERENTIATION AND A SCREENING METHOD FOR IDENTIFYING ADDITIONAL COMPOUND USEFUL FOR INDUCING NEURON CELLS DIFFERENTIATION | MUSK, TNNI3, TNNC1 | MAPT 117/4885KDM4E 400/4885CYP3A4 99/4885 |
| US-20050276764-A1 | Topical use of bis-arylimidazo[1,2-a]thiolane derivatives | ITCH, TRPA1, TPH1 | MAPT 1423/4885KDM4E 1808/4885CYP3A4 1939/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.