Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 6/20 | 0.58 |
| ▸ | AURKA | O14965 | 5/20 | 0.56 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.56 |
| ▸ | CDK1 | P06493 | 2/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.56 |
| ▸ | PRKCG | P05129 | 1/20 | 0.56 |
| ▸ | LYN | P07948 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | KIT | P10721 | 1/20 | 0.56 |
| ▸ | PIM1 | P11309 | 1/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.56 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.56 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
| ▸ | MARK3 | P27448 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzenesulfonamide SCHEMBL4876630 | 0.77 | IKBKB (0.61) | IKBKBAURKACHRNA7AURKBDKK1 | |
| SCHEMBL27782055 | 0.74 | AURKA (0.60) | IKBKBAURKAPRKCDCDK1CHEK1 | |
| SCHEMBL18594621 | 0.74 | SCN9A (0.67) | IKBKBAURKAPRKCDCDK1CHEK1 | |
| SCHEMBL3519939 | 0.74 | IKBKB (1.00) | IKBKBCDK2DKK1GSK3BMAPK8 | |
| SCHEMBL22982222 | 0.73 | MAPT (0.60) | IKBKBAURKAPRKCDCDK1CHEK1 | |
| SCHEMBL29862331 | 0.73 | MAPT (0.60) | IKBKBAURKAPRKCDCDK1CHEK1 | |
| SCHEMBL3519764 | 0.73 | IKBKB (0.97) | IKBKBDKK1GSK3BMAPK8 | |
| SCHEMBL440486 | 0.72 | AURKA (1.00) | IKBKBAURKAPRKCDCDK1CHEK1 | |
| SCHEMBL29466293 | 0.71 | MAPK8 (0.60) | IKBKBAURKAPRKCDCDK1CHEK1 | |
| SCHEMBL3575061 | 0.70 | AURKA (0.65) | IKBKBAURKAPRKCDCDK1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1269813-C | Imidazolo-5-yl-2-anilino-pyrimidines as agents for inhibition of cell proliferation | ASTRAZENECA AB (SE) | 2006-08-16 | — | — | CN | disclosed |
| CN-1231471-C | 4-Amino-5-cyano-2-anilino-pyrimidine derivatives and their use as inhibitors of cell cycle kinases | ASTRAZENECA AB (SE) | 2005-12-14 | — | — | CN | disclosed |
| CN-1196685-C | Pyrimidine derivatives | ASTRAZENCA AB (SE) | 2005-04-13 | — | — | CN | disclosed |
| CN-1454210-A | Pyrimidine derivatives | ASTRAZENCA AB (SE) | 2003-11-05 | — | — | CN | disclosed |
| CN-1452620-A | Imidazolo-5-yl-2-anilino-pyrimidines as agents for inhibition of cell proliferation | ASTRAZENECA AB (CH) | 2003-10-29 | — | — | CN | disclosed |
| CN-1419548-A | 4-amino-5-cyano-2-anilino-pyrimidine derivatives and their use as inhbitors of cell-cycle kinases | ASTRAZENECA AB (SE) | 2003-05-21 | — | — | CN | disclosed |
| EP-0053693-A1 | Penicillins, their salts, process for their preparation and pharmaceutical compositions containing them | Dr. Karl Thomae GmbH (DE) | 1982-06-16 | — | — | EP | disclosed |