Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 12/20 | 1.00 |
| ▸ | NPC1 | O15118 | 4/20 | 1.00 |
| ▸ | RAB9A | P51151 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 3/20 | 1.00 |
| ▸ | CHEK1 | O14757 | 1/20 | 1.00 |
| ▸ | IKBKB | O14920 | 1/20 | 1.00 |
| ▸ | PDPK1 | O15530 | 1/20 | 1.00 |
| ▸ | CHEK2 | O96017 | 1/20 | 1.00 |
| ▸ | PRKCG | P05129 | 1/20 | 1.00 |
| ▸ | CDK1 | P06493 | 1/20 | 1.00 |
| ▸ | LYN | P07948 | 1/20 | 1.00 |
| ▸ | KIT | P10721 | 1/20 | 1.00 |
| ▸ | PIM1 | P11309 | 1/20 | 1.00 |
| ▸ | FGFR1 | P11362 | 1/20 | 1.00 |
| ▸ | FGFR3 | P22607 | 1/20 | 1.00 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 1.00 |
| ▸ | CDK2 | P24941 | 1/20 | 1.00 |
| ▸ | MARK3 | P27448 | 1/20 | 1.00 |
| ▸ | EPHA2 | P29317 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31046509 | 0.90 | AURKA (0.81) | AURKANPC1RAB9AMAPTMAPK1 | |
| SCHEMBL4621303 | 0.90 | NPC1 (0.87) | AURKANPC1RAB9AMAPTMAPK1 | |
| SCHEMBL5384269 | 0.90 | AURKA (0.87) | AURKANPC1RAB9AMAPTMAPK1 | |
| SCHEMBL7775625 | 0.87 | AURKA (0.77) | AURKANPC1RAB9AMAPTMAPK1 | |
| SCHEMBL7775628 | 0.87 | AURKA (0.77) | AURKANPC1RAB9AMAPTMAPK1 | |
| SCHEMBL20927073 | 0.86 | AURKA (0.73) | AURKANPC1RAB9AMAPTMAPK1 | |
| SCHEMBL31046257 | 0.86 | AURKA (0.73) | AURKANPC1RAB9AMAPTMAPK1 | |
| SCHEMBL654565 | 0.85 | AURKA (0.73) | AURKANPC1RAB9AMAPTMAPK1 | |
| SCHEMBL3297883 | 0.84 | AURKA (0.71) | AURKANPC1RAB9AMAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL15487562 | 0.84 | AURKA (0.97) | AURKANPC1RAB9AMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 567 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116425735-B | 2, 4-Diphenylamine pyrimidine derivative, and preparation method and application thereof | 中南大学 | 2025-06-17 | — | — | CN | claimed |
| EP-3720493-B1 | COMBINATIONS OF RIPK1- AND IKK-INHIBITORS FOR THE PREVENTION OR TREATMENT OF IMMUNE DISEASES | UNIV KOELN (DE) | 2024-07-24 | — | — | EP | claimed |
| CN-116425735-A | 2, 4-diphenylamine pyrimidine derivative, and preparation method and application thereof | 中南大学 | 2023-07-14 | — | — | CN | claimed |
| CN-115286583-A | Diphenylaminopyrimidine-containing compound, preparation and application thereof as HDACs enzyme inhibitor | 山东大学 | 2022-11-04 | — | — | CN | claimed |
| US-20220202950-A1 | COMPOSITIONS COMPRISING BACTERIALLY DERIVED INTACT MINICELLS FOR THERANOSTIC APPLICATIONS | ENGENEIC MOLECULAR DELIVERY PTY LTD (AU) | 2022-06-30 | — | — | US | claimed |
| CN-114181160-A | 2, 4-dianilinopyrimidine-containing hydrazide derivative and preparation method and application thereof | 南通大学 | 2022-03-15 | — | — | CN | claimed |
| WO-2020222161-A1 | COMPOSITIONS COMPRISING BACTERIALLY DERIVED INTACT MINICELLS FOR THERANOSTIC APPLICATIONS | ENGENEIC MOLECULAR DELIVERY PTY LTD (AU) | 2020-11-05 | — | — | WO | claimed |
| EP-2809157-B1 | FUNGICIDAL PYRAZOLE MIXTURES | DU PONT (US) | 2017-09-06 | — | — | EP | claimed |
| EP-1661886-B1 | INSECTICIDE FOR AGRICULTURAL OR HORTICULTURAL USE AND METHOD OF USE THEREOF | MITSUI CHEMICALS AGRO INC (JP) | 2016-08-10 | — | — | EP | claimed |
| EP-2557925-B1 | CO-CRYSTALS OF CYPRODINIL | SYNGENTA LTD (GB) | 2016-06-22 | — | — | EP | claimed |
| EP-1824856-B1 | 2,4 (4,6) PYRIMIDINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2013-10-23 | — | — | EP | claimed |
| US-8148388-B2 | 2,4 (4,6) pyrimidine derivatives | JANSSEN PHARMACEUTICA, N.V. (BE) | 2012-04-03 | — | — | US | claimed |
| EP-2201001-B1 | NOVEL IMIDAZOLE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-09-14 | — | — | EP | claimed |
| US-20100160310-A1 | 2,4 (4,6) PYRIMIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-06-24 | — | — | US | claimed |
| EP-1824856-A1 | 2,4 (4,6) PYRIMIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-08-29 | — | — | EP | claimed |
| WO-2006061415-A1 | 2,4 (4,6) PYRIMIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-15 | — | — | WO | claimed |
| EP-1132387-B1 | PYRIMIDINYLBENZIMIDAZOLE AND TRIAZINYLBENZIMIDAZOLE DERIVATIVES AND AGRICULTURAL/HORTICULTURAL FUNGICIDES | KUMIAI CHEMICAL INDUSTRY CO (JP) | 2005-09-28 | — | — | EP | claimed |
| EP-1411766-B1 | FUNGICIDAL COMPOSITION AND USE OF THIS COMPOSITION FOR CONTROLLING PLANT DISEASES | BAYER CROPSCIENCE SA (FR) | 2005-03-16 | — | — | EP | claimed |
| EP-0793914-B1 | Fungicidal Composition | SUMITOMO CHEMICAL CO (JP) | 1999-09-15 | — | — | EP | claimed |
| EP-0347866-B1 | ANILINOPYRIMIDINE DERIVATIVES | IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) | 1993-04-07 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160310-A1 | 2,4 (4,6) PYRIMIDINE DERIVATIVES | NR1H3, NR1H2, NR0B1 | AURKA 4202/4885NPC1 394/4885RAB9A 3616/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.