Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 13/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | BUB1 | O43683 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19032173 | 0.76 | BRD4 (0.52) | BRD4PDGFRAMAPK8CDK5CLK4 | |
| SCHEMBL15328755 | 0.76 | BRD4 (1.00) | BRD4CREBBP | |
| SCHEMBL4467904 | 0.75 | MAPT (0.49) | BRD4KMT2AL3MBTL1PTK2BUB1 | |
| SCHEMBL9803050 | 0.74 | L3MBTL1 (0.48) | BRD4KMT2AL3MBTL1PTK2BUB1 | |
| SCHEMBL934852 | 0.73 | PTK2 (0.61) | BRD4L3MBTL1PTK2NPC1LMNA | |
| SCHEMBL24263871 | 0.73 | BRD4 (0.94) | BRD4CREBBP | |
| SCHEMBL31027151 | 0.68 | DYRK1A (0.58) | KMT2ALMNAGAAHTTSMN1; SMN2 | |
| SCHEMBL6907631 | 0.68 | PTK2 (0.46) | BRD4L3MBTL1PTK2LMNATSHR | |
| SCHEMBL23537356 | 0.68 | PARP1 (0.59) | BRD4KMT2AL3MBTL1PTK2BUB1 | |
| SCHEMBL29824193 | 0.68 | PARP1 (0.59) | BRD4KMT2AL3MBTL1PTK2BUB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0015523-B1 | INDOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE FOR MEDICAMENTS | Dr. Karl Thomae GmbH (DE) | 1982-10-13 | — | — | EP | disclosed |
| US-4343811-A | ATHEROSCLEROSIS | BOEHRINGER INGELHEIM GMBH (DE) | 1982-08-10 | — | — | US | disclosed |
| EP-0015523-A1 | Indole derivatives, their preparation and their use for medicaments | Dr. Karl Thomae GmbH (DE) | 1980-09-17 | — | — | EP | disclosed |