Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11265315 | 0.90 | BRD4 (0.42) | BRD4TP53CREBBPESR2POLB | |
| Morpholine SCHEMBL11273353 | 0.90 | ACHE (0.40) | BRD4TP53CREBBPESR2POLB | |
| Methylpiperazine SCHEMBL11281700 | 0.89 | ALDH1A1 (0.35) | BRD4TP53CREBBPACHEALDH1A1 | |
| Water SCHEMBL11300319 | 0.89 | BRD4 (0.41) | BRD4TP53CREBBPESR2POLB | |
| Water SCHEMBL11271972 | 0.89 | BRD4 (0.41) | BRD4TP53CREBBPESR2POLB | |
| Water SCHEMBL11268513 | 0.89 | BRD4 (0.41) | BRD4TP53CREBBPESR2POLB | |
| SCHEMBL11304268 | 0.84 | BRD4 (0.37) | BRD4TP53CREBBPESR2POLB | |
| SCHEMBL11383390 | 0.83 | BRD4 (0.40) | BRD4TP53CREBBPESR2POLB | |
| Water SCHEMBL11268487 | 0.81 | BRD4 (0.40) | BRD4TP53CREBBPESR2POLB | |
| SCHEMBL11390336 | 0.74 | POLB (0.52) | POLBLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0029990-B1 | BIPHENYLMETHANE DERIVATIVE, METHODS FOR ITS PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1982-09-08 | — | — | EP | disclosed |
| EP-0029990-A1 | Biphenylmethane derivative, methods for its production and pharmaceutical compositions containing it | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1981-06-10 | — | — | EP | disclosed |