Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.55 |
| ▸ | MMP1 | P03956 | 1/20 | 0.51 |
| ▸ | MMP3 | P08254 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.43 |
| ▸ | EP300 | Q09472 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 3/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11267531 | 0.83 | MMP1 (0.56) | HDAC6MMP1MMP3MMP9CNR2 | |
| SCHEMBL11264078 | 0.83 | HDAC6 (0.74) | HDAC6EP300GSK3AGSK3B | |
| SCHEMBL11269906 | 0.82 | MMP1 (0.54) | HDAC6MMP1MMP3MMP9CNR2 | |
| SCHEMBL11266702 | 0.80 | MMP1 (0.47) | HDAC6MMP1MMP3MMP9EP300 | |
| SCHEMBL11270800 | 0.78 | HDAC6 (0.52) | HDAC6MMP1MMP3MMP9GFER | |
| SCHEMBL23873935 | 0.77 | CAPN1 (0.67) | HDAC6MMP1MMP3MMP9GFER | |
| SCHEMBL25937447 | 0.77 | CAPN1 (0.67) | HDAC6MMP1MMP3MMP9GFER | |
| SCHEMBL20516454 | 0.75 | HDAC6 (0.53) | HDAC6MMP1MMP3MMP9GFER | |
| SCHEMBL20516455 | 0.75 | HDAC6 (0.53) | HDAC6MMP1MMP3MMP9GFER | |
| SCHEMBL11259949 | 0.74 | HDAC6 (0.62) | HDAC6MMP1MMP3MMP9EP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0005647-B1 | HYDANTOIN COMPOUNDS, THEIR PREPARATION AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM | Lilly Industries Limited (GB) | 1982-06-09 | — | — | EP | disclosed |
| US-4293563-A | ANTIASTHMATICS | LILLY INDUSTRIES LIMITED (GB) | 1981-10-06 | — | — | US | disclosed |
| US-4241073-A | ASTHMA | LILLY INDUSTRIES LIMITED (GB) | 1980-12-23 | — | — | US | disclosed |
| EP-0005647-A1 | Hydantoin compounds, their preparation and pharmaceutical formulations containing them | Lilly Industries Limited (GB) | 1979-11-28 | — | — | EP | disclosed |