Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | AKT2 | P31751 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | PAK4 | O96013 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | PRKCG | P05129 | 1/20 | 0.34 |
| ▸ | INSR | P06213 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1127247 | 0.83 | HTT (0.48) | HTTPARP1AKT1AKT2ALDH1A1 | |
| SCHEMBL1127274 | 0.83 | HTT (0.44) | HTTPARP1AKT1AKT2ALDH1A1 | |
| SCHEMBL1127088 | 0.82 | HTT (0.47) | HTTPARP1AKT1AKT2ALDH1A1 | |
| SCHEMBL1127206 | 0.81 | HTT (0.46) | HTTPARP1AKT1AKT2ALDH1A1 | |
| SCHEMBL1127466 | 0.80 | HTT (0.41) | HTTPARP1ALDH1A1POLBDYRK1A | |
| SCHEMBL1126606 | 0.79 | CDC7 (0.46) | HTTALDH1A1DYRK1ACDC7PLK4 | |
| SCHEMBL1127151 | 0.79 | HTT (0.43) | HTTPARP1AKT1AKT2ALDH1A1 | |
| SCHEMBL1126627 | 0.77 | HTT (0.45) | HTTPARP1AKT1AKT2ALDH1A1 | |
| SCHEMBL1126791 | 0.76 | HTT (0.44) | HTTPARP1AKT1AKT2ALDH1A1 | |
| SCHEMBL1126755 | 0.76 | HTT (0.43) | HTTPARP1AKT1AKT2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2283006-A1 | PYRROLE ANTIFUNGAL AGENTS | F2G Limited (GB) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009130481-A1 | PYRROLE ANTIFUNGAL AGENTS | F2G LTD (GB) | 2009-10-29 | — | — | WO | disclosed |