SCHEMBL1126727

SCHEMBL1126727

Ic1cc2n(c1)CCOC2

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20150247 0.76 GAA (0.33)
SCHEMBL31352265 0.76 MGLL (0.32)
SCHEMBL15894116 0.76 DRD3 (0.37)
SCHEMBL21576049 0.73 NPC1 (0.33)
SCHEMBL23480621 0.72 SIGMAR1 (0.33)
SCHEMBL21576645 0.72 DRD3 (0.33)
SCHEMBL21570108 0.71 POLB (0.42)
SCHEMBL31352213 0.69 KDM4E (0.36)
SCHEMBL23386845 0.69 NPC1 (0.38)
SCHEMBL24158877 0.67 PIK3CA (0.38)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170327497-A1 SUBSTITUTED 6-AZA-ISOINDOLIN-1-ONE DERIVATIVES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2017-11-16 US disclosed
US-20170327497-A1 SUBSTITUTED 6-AZA-ISOINDOLIN-1-ONE DERIVATIVES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2017-11-16 US disclosed
US-20170327497-A1 SUBSTITUTED 6-AZA-ISOINDOLIN-1-ONE DERIVATIVES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2017-11-16 US disclosed
US-9663514-B2 Substituted 6-aza-isoindolin-1-one derivatives TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2017-05-30 US disclosed
US-9663514-B2 Substituted 6-aza-isoindolin-1-one derivatives TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2017-05-30 US disclosed
US-9663514-B2 Substituted 6-aza-isoindolin-1-one derivatives TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2017-05-30 US disclosed
US-9452168-B2 Pyrrole antifungal agents F2G LTD (GB) 2016-09-27 US disclosed
EP-2723739-B1 SUBSTITUTED 6-AZA-ISOINDOLIN-1-ONE DERIVATIVES TAKEDA PHARMACEUTICAL (JP) 2016-08-24 EP disclosed
EP-2723739-B1 SUBSTITUTED 6-AZA-ISOINDOLIN-1-ONE DERIVATIVES TAKEDA PHARMACEUTICAL (JP) 2016-08-24 EP disclosed
US-20150274723-A1 SUBSTITUTED 6-AZA-ISOINDOLIN-1-ONE DERIVATIVES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2015-10-01 US disclosed
EP-2626361-B1 Pyrrole antifungal agents F2G LTD (GB) 2014-10-15 EP disclosed
US-20140206680-A1 SUBSTITUTED 6-AZA-ISOINDOLIN-1-ONE DERIVATIVES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2014-07-24 US disclosed
US-20140206680-A1 SUBSTITUTED 6-AZA-ISOINDOLIN-1-ONE DERIVATIVES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2014-07-24 US disclosed
US-20140206680-A1 SUBSTITUTED 6-AZA-ISOINDOLIN-1-ONE DERIVATIVES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2014-07-24 US disclosed
EP-2723739-A1 SUBSTITUTED 6-AZA-ISOINDOLIN-1-ONE DERIVATIVES Takeda Pharmaceutical Company Limited (JP) 2014-04-30 EP disclosed
EP-2626361-A1 Pyrrole antifungal agents F2G Limited (GB) 2013-08-14 EP disclosed
WO-2012177714-A1 SUBSTITUTED 6-AZA-ISOINDOLIN-1-ONE DERIVATIVES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2012-12-27 WO disclosed
US-20110152285-A1 PYRROLE ANTIFUNGAL AGENTS F2G LTD (GB) 2011-06-23 US disclosed
EP-2283006-A1 PYRROLE ANTIFUNGAL AGENTS F2G Limited (GB) 2011-02-16 EP disclosed
WO-2009130481-A1 PYRROLE ANTIFUNGAL AGENTS F2G LTD (GB) 2009-10-29 WO disclosed