Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 1/20 | 0.68 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.50 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.49 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.49 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2762171 | 0.89 | APEX1 (0.79) | APEX1HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL11263079 | 0.87 | APEX1 (0.70) | APEX1PTGDR2POLBSMN1; SMN2GLA | |
| SCHEMBL11259242 | 0.85 | APEX1 (0.68) | APEX1PTGDR2SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL11808900 | 0.82 | APEX1 (1.00) | APEX1POLBSMN1; SMN2GLAKDM4E | |
| SCHEMBL11260693 | 0.82 | APEX1 (0.62) | APEX1PTGDR2SMN1; SMN2 | |
| SCHEMBL11257792 | 0.82 | MEN1 (0.64) | APEX1PTGDR2HDAC1HDAC11HDAC8 | |
| SCHEMBL11264725 | 0.80 | APEX1 (0.64) | APEX1PTGDR2POLBSMN1; SMN2GLA | |
| SCHEMBL27110208 | 0.79 | APEX1 (0.63) | APEX1PTGDR2POLBSMN1; SMN2GLA | |
| SCHEMBL18555697 | 0.79 | PTGS2 (0.52) | MEN1KMT2A | |
| SCHEMBL11257423 | 0.78 | APEX1 (0.60) | APEX1POLBSMN1; SMN2GLAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0019440-B1 | BENZIMIDAZOLONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PFIZER INC. (US) | 1982-09-29 | — | — | EP | disclosed |
| EP-0019440-A1 | Benzimidazolone derivatives, process for their preparation and pharmaceutical compositions containing them | PFIZER INC. (US) | 1980-11-26 | — | — | EP | disclosed |
| US-4209527-A | ANTIDIABETIC AGENTS | PFIZER INC. (US) | 1980-06-24 | — | — | US | disclosed |