Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RGS12 | O14924 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ALPI | P09923 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | XIAP | P98170 | 1/20 | 0.46 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.46 |
| ▸ | CTSC | P53634 | 1/20 | 0.45 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1126415 | 0.75 | CCKAR (0.60) | — | |
| D-Phenylalanine SCHEMBL11422526 | 0.74 | SLC7A5 (0.58) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL6666687 | 0.74 | ALPI (0.46) | TSHRALPIPKMPTGS1XIAP | |
| SCHEMBL5742102 | 0.73 | CRBN (0.57) | OPRM1OPRD1 | |
| SCHEMBL30694233 | 0.73 | CRBN (0.57) | OPRM1OPRD1 | |
| SCHEMBL7363047 | 0.73 | CTSL (0.66) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL7361168 | 0.73 | CTSL (0.66) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL7436896 | 0.73 | CTSK (0.67) | LTA4H | |
| Hydrochloric Acid SCHEMBL31551114 | 0.73 | CRBN (0.56) | OPRM1OPRD1 | |
| Hydrochloric Acid SCHEMBL30694225 | 0.73 | CRBN (0.56) | OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110263486-A1 | Inhibitors of Cancer Cell, T-Cell and Keratinocyte Proliferation | 4SC AG (DE) | 2011-10-27 | — | — | US | disclosed |
| EP-2284179-A2 | Inhibitors of cancer cell, T-cell and keratinocyte proliferation | 4SC AG (DE) | 2011-02-16 | — | — | EP | disclosed |
| EP-2284178-A2 | Inhibitors of cancer cell, T-cell and keratinocyte proliferation | 4SC AG (DE) | 2011-02-16 | — | — | EP | disclosed |
| US-20090176716-A1 | INHIBITORS OF CANCER CELL, T-CELL AND KERATINOCYTE PROLIFERATION | LEBAN JOHANN | 2009-07-09 | — | — | US | disclosed |
| US-7531517-B2 | Inhibitors of cancer cell, T-cell and keratinocyte proliferation | 4SC AG (DE) | 2009-05-12 | — | — | US | disclosed |
| EP-1922327-A2 | INHIBITORS OF CANCER CELL, T-CELL AND KERATINOCYTE PROLIFERATION | 4SC AG (DE) | 2008-05-21 | — | — | EP | disclosed |
| US-20070037753-A1 | Inhibitors of cancer cell, T-cell and keratinocyte proliferation | 4SC AG (DE) | 2007-02-15 | — | — | US | disclosed |
| WO-2007017284-A2 | INHIBITORS OF CANCER CELL, T-CELL AND KERATINOCYTE PROLIFERATION | 4SC AG (DE) | 2007-02-15 | — | — | WO | disclosed |
| EP-1752467-A1 | Inhibitors of cancer cell, t-cell and keratinocyte proliferation | 4SC AG (DE) | 2007-02-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090176716-A1 | INHIBITORS OF CANCER CELL, T-CELL AND KERATINOCYTE PROLIFERATION | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, EGFR, MKI67 | RGS12 2813/4885TSHR 230/4885ALPI 4413/4885 |
| US-20070037753-A1 | Inhibitors of cancer cell, T-cell and keratinocyte proliferation | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, EGFR, MKI67 | RGS12 2865/4885TSHR 219/4885ALPI 4456/4885 |
| US-20110263486-A1 | Inhibitors of Cancer Cell, T-Cell and Keratinocyte Proliferation | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, EGFR, MKI67 | RGS12 2697/4885TSHR 223/4885ALPI 4372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.