⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27822531 | 0.93 | ALDH1A1 (0.50) | — | |
| SCHEMBL2522581 | 0.84 | — | — | |
| SCHEMBL1410363 | 0.82 | — | — | |
| SCHEMBL11226078 | 0.82 | CHRNB2 (0.35) | — | |
| SCHEMBL5193238 | 0.80 | — | — | |
| SCHEMBL1131957 | 0.80 | — | — | |
| SCHEMBL1858618 | 0.78 | — | — | |
| SCHEMBL22052 | 0.78 | ALDH1A1 (0.48) | — | |
| SCHEMBL4631621 | 0.78 | — | — | |
| SCHEMBL1410399 | 0.78 | ALDH1A1 (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4604955-A1 | USE OF PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 3 COMPOUNDS | Pfizer Inc. (US) | 2025-08-27 | — | — | EP | disclosed |
| EP-4605076-A1 | PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 3 (PNPLA3) MODIFIERS | Pfizer Inc. (US) | 2025-08-27 | — | — | EP | disclosed |
| CN-120129681-A | Modulators of protein 3 (PNPLA 3) containing Patatin-like phospholipase domains | 辉瑞大药厂 | 2025-06-10 | — | — | CN | disclosed |
| WO-2024084363-A1 | USE OF PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 3 COMPOUNDS | PFIZER INC. (US) | 2024-04-25 | — | — | WO | disclosed |
| WO-2024084363-A1 | USE OF PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 3 COMPOUNDS | PFIZER INC. (US) | 2024-04-25 | — | — | WO | disclosed |
| WO-2024084360-A1 | PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 3 (PNPLA3) MODIFIERS | PFIZER INC. (US) | 2024-04-25 | — | — | WO | disclosed |
| US-4356121-A | Process for the production of N-cyanolactams | CIBA-GEIGY CORPORATION (US) | 1982-10-26 | — | — | US | disclosed |