Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ASAH1 | Q13510 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9060998 | 0.73 | TDP1 (0.48) | ASAH1SMN1; SMN2LMNAHSD17B10APAF1 | |
| SCHEMBL2924425 | 0.73 | TDP1 (0.42) | KDM4ENPC1ASAH1SMN1; SMN2LMNA | |
| SCHEMBL20683088 | 0.70 | TDP1 (0.48) | ASAH1SMN1; SMN2LMNAHSD17B10HTT | |
| SCHEMBL8792548 | 0.70 | TDP1 (0.46) | ASAH1SMN1; SMN2LMNAHSD17B10HTT | |
| SCHEMBL8413080 | 0.70 | TDP1 (0.48) | ASAH1SMN1; SMN2LMNAEGLN3HTT | |
| SCHEMBL7491390 | 0.69 | TDP1 (0.44) | KDM4ENPC1ASAH1SMN1; SMN2LMNA | |
| SCHEMBL11140162 | 0.68 | ASAH1 (0.47) | ASAH1SMN1; SMN2LMNAHTT | |
| SCHEMBL29195662 | 0.68 | ASAH1 (0.44) | KDM4ENPC1ASAH1SMN1; SMN2LMNA | |
| SCHEMBL30846016 | 0.68 | ASAH1 (0.44) | KDM4ENPC1ASAH1SMN1; SMN2LMNA | |
| SCHEMBL9460847 | 0.68 | POLB (0.40) | KDM4ENPC1ASAH1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4329363-A | Substituted mercapto acid amides and their use | MERCK & CO., INC. (US) | 1982-05-11 | — | — | US | disclosed |
| US-4216160-A | IMMUNOREGULANTS FOR CORRECTING AN INBALANCE OF IMMUNE HOMEOSTASIS | MERCK & CO., INC. (US) | 1980-08-05 | — | — | US | disclosed |