Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 4/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11056054 | 0.90 | SCN5A (0.46) | SCN5ACACNA1CALDH1A1GAAKMT2A | |
| SCHEMBL11268006 | 0.86 | SCN5A (0.41) | SCN5ACACNA1CALDH1A1CA12CA1 | |
| SCHEMBL11141127 | 0.85 | GAA (0.49) | ALDH1A1GAAKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL11414104 | 0.85 | SCN5A (0.39) | SCN5ACACNA1CALDH1A1GAAKMT2A | |
| SCHEMBL11265596 | 0.84 | SCN5A (0.38) | SCN5ACACNA1CKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL11278876 | 0.84 | SCN5A (0.38) | SCN5ACACNA1CALDH1A1CA1CA2 | |
| SCHEMBL11053535 | 0.83 | DRD2 (0.39) | ALDH1A1GAACA12CA1CA2 | |
| SCHEMBL11431492 | 0.83 | ALDH1A1 (0.52) | ALDH1A1GAACA12CA1CA2 | |
| SCHEMBL11057583 | 0.81 | SCN5A (0.46) | SCN5ACACNA1CALDH1A1KMT2AMAPT | |
| SCHEMBL10941132 | 0.78 | CACNA1C (0.56) | SCN5ACACNA1CALDH1A1DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4326075-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4203920-A | ANTIDIARRHEAL | WILLIAM H. RORER, INC. (US) | 1980-05-20 | — | — | US | disclosed |
| US-4060635-A | Amidinoureas for treating diarrhea | WILLIAM H. RORER, INC. (US) | 1977-11-29 | — | — | US | disclosed |