Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.44 |
| ▸ | DRD1 | P21728 | 7/20 | 0.44 |
| ▸ | DRD3 | P35462 | 6/20 | 0.44 |
| ▸ | DRD5 | P21918 | 5/20 | 0.44 |
| ▸ | DRD4 | P21917 | 3/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 2/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.40 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26777408 | 0.86 | CRBN (0.41) | DRD2DRD1DRD3DRD5DRD4 | |
| SCHEMBL28873244 | 0.85 | DRD2 (0.54) | DRD2DRD1DRD3DRD5DRD4 | |
| SCHEMBL26768680 | 0.79 | CRBN (0.40) | DRD2DRD1DRD3DRD5DRD4 | |
| SCHEMBL2371462 | 0.79 | DRD2 (0.48) | DRD2DRD1DRD3DRD5DRD4 | |
| Bromide SCHEMBL29853685 | 0.78 | CRBN (0.39) | DRD2DRD1DRD3DRD5DRD4 | |
| SCHEMBL27227663 | 0.78 | L3MBTL3 (0.57) | DRD2DRD1DRD3DRD5DRD4 | |
| SCHEMBL30658342 | 0.78 | L3MBTL3 (0.57) | DRD2DRD1DRD3DRD5DRD4 | |
| SCHEMBL31748922 | 0.78 | ESR2 (0.54) | DRD2DRD1DRD3DRD5DRD4 | |
| SCHEMBL26767825 | 0.78 | ESR2 (0.39) | DRD2DRD1DRD3DRD5DRD4 | |
| SCHEMBL12498872 | 0.76 | DPP4 (0.44) | HDAC4ABHD6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4351842-A | N-Cyclopropylisoindolines | GLAXO LABORATORIES LIMITED (GB) | 1982-09-28 | — | — | US | claimed |
| US-4351842-A | N-Cyclopropylisoindolines | GLAXO LABORATORIES LIMITED (GB) | 1982-09-28 | — | — | US | disclosed |