Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC42 | P60953 | 3/20 | 0.47 |
| ▸ | RAC1 | P63000 | 3/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11265451 | 0.87 | CDC42 (0.60) | CDC42RAC1PTGS2PTGS1NPC1 | |
| SCHEMBL11278560 | 0.87 | CDC42 (0.46) | CDC42RAC1PTGS2PTGS1NPC1 | |
| SCHEMBL11271813 | 0.86 | NPC1 (0.47) | CDC42RAC1PTGS2PTGS1NPC1 | |
| SCHEMBL11064934 | 0.81 | CDC42 (0.49) | CDC42RAC1PTGS2PTGS1NPC1 | |
| SCHEMBL11357953 | 0.81 | PTGS2 (0.74) | CDC42RAC1PTGS2PTGS1NPC1 | |
| SCHEMBL11602531 | 0.79 | CDC42 (0.47) | CDC42RAC1PTGS2PTGS1NPC1 | |
| SCHEMBL11273207 | 0.77 | CDC42 (0.45) | CDC42RAC1PTGS2PTGS1NPC1 | |
| SCHEMBL10815779 | 0.77 | CDC42 (0.45) | CDC42RAC1PTGS2PTGS1NPC1 | |
| SCHEMBL11269293 | 0.77 | NPC1 (0.42) | CDC42RAC1PTGS2PTGS1NPC1 | |
| SCHEMBL11272575 | 0.77 | CDC42 (0.42) | CDC42RAC1PTGS2PTGS1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4344943-A | ANALGESICS, ANTIINFLAMMATORY AGENTS | SYNTEX (U.S.A.) INC. (US) | 1982-08-17 | — | — | US | disclosed |
| EP-0041711-A1 | 6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo(1,2-a)-pyrrole-1-carboxylic acids and derivatives thereof, process for their production and pharmaceutical compositions containing them | SYNTEX (U.S.A.) INC. (US) | 1981-12-16 | — | — | EP | disclosed |