Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.65 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.64 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.64 |
| ▸ | ITGAL | P20701 | 1/20 | 0.64 |
| ▸ | ECE1 | P42892 | 5/20 | 0.63 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11491748 | 1.00 | ACE (0.68) | ACEALOX15ITGB2ICAM1ITGAL | |
| SCHEMBL11495529 | 0.90 | ACE (0.71) | ACEALOX15ITGB2ICAM1ITGAL | |
| SCHEMBL11495534 | 0.90 | ACE (0.71) | ACEALOX15ITGB2ICAM1ITGAL | |
| SCHEMBL31520113 | 0.89 | ACE (0.67) | ACEALOX15ITGB2ICAM1ITGAL | |
| SCHEMBL11382215 | 0.89 | ALOX15 (0.70) | ACEALOX15ITGB2ICAM1ITGAL | |
| SCHEMBL19051476 | 0.89 | ACE (0.67) | ACEALOX15ITGB2ICAM1ITGAL | |
| SCHEMBL4270030 | 0.89 | ERAP2 (0.67) | ACEALOX15ITGB2ICAM1ITGAL | |
| SCHEMBL11382213 | 0.89 | ALOX15 (0.70) | ACEALOX15ITGB2ICAM1ITGAL | |
| SCHEMBL28401650 | 0.88 | ALOX15 (0.69) | ACEALOX15ITGB2ICAM1ITGAL | |
| SCHEMBL28401652 | 0.88 | ALOX15 (0.69) | ACEALOX15ITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4199512-A | Compounds for alleviating hypertension | E. R. SQUIBB & SONS, INC. (US) | 1980-04-22 | — | — | US | claimed |
| US-4140786-A | ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1979-02-20 | — | — | US | claimed |
| WO-2021255156-A1 | NOVEL DIPEPTIDE COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND A NOVEL THERAPEUTIC USE OF DIPEPTIDE COMPOUNDS | Universite Paris-Saclay (FR) | 2021-12-23 | — | — | WO | disclosed |
| US-4339600-A | ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1982-07-13 | — | — | US | disclosed |
| US-4199512-A | Compounds for alleviating hypertension | E. R. SQUIBB & SONS, INC. (US) | 1980-04-22 | — | — | US | disclosed |
| US-4173704-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1979-11-06 | — | — | US | disclosed |
| US-4140797-A | MERCAPTOACYL AMINO ACIDS, ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1979-02-20 | — | — | US | disclosed |
| US-4140786-A | ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1979-02-20 | — | — | US | disclosed |
| US-4112119-A | MERCAPTOACYL AMINOACIDS | E. R. SQUIBB & SONS, INC. (US) | 1978-09-05 | — | — | US | disclosed |
| US-4053651-A | MERCAPTOACYL AMINO ACIDS, ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1977-10-11 | — | — | US | disclosed |