Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL5699521 | 1.00 | TDP1 (0.62) | TDP1TSHRMAPK1ALDH1A1LMNA | |
| 1,4-Butanediol SCHEMBL3838368 | 0.87 | TDP1 (0.48) | TDP1TSHRMAPK1ALDH1A1LMNA | |
| 1,6-Hexanediol SCHEMBL17272612 | 0.87 | TDP1 (0.48) | TDP1TSHRMAPK1ALDH1A1LMNA | |
| Isopropyl Alcohol SCHEMBL28257527 | 0.87 | ALDH1A1 (0.43) | TDP1TSHRMAPK1ALDH1A1LMNA | |
| SCHEMBL9292760 | 0.84 | TDP1 (0.39) | TDP1TSHRMAPK1ALDH1A1LMNA | |
| Propylene Glycol SCHEMBL28121845 | 0.83 | TDP1 (0.77) | TDP1TSHRMAPK1ALDH1A1LMNA | |
| E968 SCHEMBL25242384 | 0.81 | LMNA (0.42) | TDP1TSHRMAPK1ALDH1A1LMNA | |
| Glycerin SCHEMBL2869711 | 0.81 | LMNA (0.56) | TDP1TSHRALDH1A1LMNA | |
| SCHEMBL3189647 | 0.81 | TSHR (0.41) | TDP1TSHR | |
| Glycerin SCHEMBL27737471 | 0.81 | LMNA (0.56) | TDP1TSHRALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023219658-A2 | MULTI-LAYERED COATED METAL SUBSTRATES | PRC-DESOTO INTERNATIONAL, INC. (US) | 2023-11-16 | — | — | WO | disclosed |
| US-20210363358-A1 | Coating Compositions Having Improved Corrosion Resistance | PPG INDUSTRIES OHIO, INC. (US) | 2021-11-25 | — | — | US | disclosed |
| EP-3728484-A1 | COATING COMPOSITIONS HAVING IMPROVED CORROSION RESISTANCE | PPG Industries Ohio, Inc. (US) | 2020-10-28 | — | — | EP | disclosed |
| US-4352899-A | EPOXY RESIN, ORGANIC PHOSPHORUS COMPOUND, ZINC POWDER, MAGNESIUM COMPOUND | SAKAI CHEMICAL INDUSTRY CO., LTD. (JP) | 1982-10-05 | — | — | US | disclosed |