Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | NSD2 | O96028 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | PPIA | P62937 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL920392 | 0.89 | NSD2 (0.66) | NSD2SMN1; SMN2POLBLMNAMAPK8 | |
| SCHEMBL7171835 | 0.81 | POLB (0.62) | NSD2SMN1; SMN2POLBLMNAMAPK8 | |
| SCHEMBL28871455 | 0.79 | HTT (0.55) | SMN1; SMN2LMNAALDH1A1KMT2AKDR | |
| SCHEMBL7311399 | 0.77 | KMT2A (0.70) | SMN1; SMN2POLBLMNAALDH1A1HPGD | |
| SCHEMBL22092983 | 0.76 | TP53 (0.50) | TP53SMN1; SMN2POLBPPIAALDH1A1 | |
| SCHEMBL27819658 | 0.75 | POLB (0.60) | NSD2SMN1; SMN2POLBLMNAMAPK8 | |
| SCHEMBL5009903 | 0.75 | SMN1; SMN2 (0.50) | NSD2SMN1; SMN2POLBLMNAMAPK8 | |
| SCHEMBL6972329 | 0.75 | SMN1; SMN2 (0.61) | SMN1; SMN2POLBLMNAALDH1A1HPGD | |
| SCHEMBL28354844 | 0.74 | KMT2A (0.66) | SMN1; SMN2POLBLMNAALDH1A1HPGD | |
| SCHEMBL29516862 | 0.74 | POLB (0.64) | SMN1; SMN2POLBLMNAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0004187-B1 | HETEROCYCLYLCARBONYL DERIVATIVES OF UREA AND THEIR USE AS AGENTS FOR DISSOLUTION OF GALLSTONES | PFIZER INC. (US) | 1982-03-17 | — | — | EP | claimed |
| EP-0004187-A1 | Heterocyclylcarbonyl derivatives of urea and their use as agents for dissolution of gallstones | PFIZER INC. (US) | 1979-09-19 | — | — | EP | claimed |
| EP-0004187-B1 | HETEROCYCLYLCARBONYL DERIVATIVES OF UREA AND THEIR USE AS AGENTS FOR DISSOLUTION OF GALLSTONES | PFIZER INC. (US) | 1982-03-17 | — | — | EP | disclosed |
| EP-0004187-A1 | Heterocyclylcarbonyl derivatives of urea and their use as agents for dissolution of gallstones | PFIZER INC. (US) | 1979-09-19 | — | — | EP | disclosed |
| US-4163784-A | ACYLUREA DERIVATIVES | PFIZER INC. (US) | 1979-08-07 | — | — | US | disclosed |