Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | SLC6A15 | Q9H2J7 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.32 |
| ▸ | BRAF | P15056 | 5/20 | 0.31 |
| ▸ | JAK2 | O60674 | 2/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | PLK4 | O00444 | 1/20 | 0.31 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.31 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.31 |
| ▸ | ULK1 | O75385 | 1/20 | 0.31 |
| ▸ | ERN1 | O75460 | 1/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | KRAS | P01116 | 1/20 | 0.31 |
| ▸ | RAF1 | P04049 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1127226 | 0.87 | SMARCA2 (0.37) | HDAC2NR1I2BRAFJAK2OPRD1 | |
| SCHEMBL1870443 | 0.85 | BRAF (0.44) | HDAC2NR1I2BRAFJAK2PLK4 | |
| SCHEMBL1127105 | 0.85 | BRAF (0.48) | HDAC2NR1I2BRAFJAK2PLK4 | |
| SCHEMBL1127352 | 0.85 | NR1I2 (0.33) | HRH1SLC6A15HDAC2NR1I2BRAF | |
| SCHEMBL1127223 | 0.85 | NR1I2 (0.43) | HRH1SLC6A15NR1I2BRAFMAPK14 | |
| SCHEMBL1127270 | 0.83 | BRAF (0.38) | HDAC2NR1I2BRAFJAK2PLK4 | |
| SCHEMBL1873587 | 0.80 | BRAF (0.45) | NR1I2BRAFJAK2PLK4EPHB6 | |
| SCHEMBL1127563 | 0.80 | BRAF (0.58) | HDAC2NR1I2BRAFJAK2PLK4 | |
| SCHEMBL12669048 | 0.79 | BRAF (0.35) | NR1I2BRAFJAK2PLK4EPHB6 | |
| SCHEMBL1127193 | 0.78 | BRAF (0.46) | HDAC2NR1I2BRAFJAK2PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2498608-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GlaxoSmithKline LLC (US) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011059610-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-05-19 | — | — | WO | disclosed |
| EP-2282636-A2 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GlaxoSmithKline LLC (US) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009137391-A2 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-11-12 | — | — | WO | disclosed |