Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 3/20 | 0.33 |
| ▸ | BRAF | P15056 | 9/20 | 0.33 |
| ▸ | SLC6A15 | Q9H2J7 | 2/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | PLK4 | O00444 | 1/20 | 0.31 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.31 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | ULK1 | O75385 | 1/20 | 0.31 |
| ▸ | ERN1 | O75460 | 1/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | KRAS | P01116 | 1/20 | 0.31 |
| ▸ | RAF1 | P04049 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1127350 | 0.90 | NR1I2 (0.35) | NR1I2BRAFHDAC3HDAC1HDAC7 | |
| SCHEMBL31111954 | 0.90 | NR1I2 (0.35) | NR1I2BRAFHDAC3HDAC1HDAC7 | |
| SCHEMBL1127440 | 0.87 | NR1I2 (0.44) | NR1I2BRAFCSNK1DCSNK1E | |
| SCHEMBL12669047 | 0.86 | BRAF (0.35) | NR1I2BRAFHDAC3HDAC1HDAC7 | |
| SCHEMBL1127227 | 0.85 | HRH1 (0.35) | NR1I2BRAFSLC6A15HRH1HDAC2 | |
| SCHEMBL1870443 | 0.85 | BRAF (0.44) | NR1I2BRAFHDAC3HDAC1HDAC7 | |
| SCHEMBL1127105 | 0.85 | BRAF (0.48) | NR1I2BRAFHDAC3HDAC1HDAC7 | |
| SCHEMBL1127270 | 0.83 | BRAF (0.38) | NR1I2BRAFHDAC3HDAC1HDAC7 | |
| SCHEMBL12349960 | 0.80 | BRAF (0.46) | NR1I2BRAFHDAC3HDAC1HDAC7 | |
| SCHEMBL12668192 | 0.79 | MEN1 (0.35) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2498608-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GlaxoSmithKline LLC (US) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011059610-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-05-19 | — | — | WO | disclosed |
| EP-2282636-A2 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GlaxoSmithKline LLC (US) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009137391-A2 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-11-12 | — | — | WO | disclosed |