Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 3/20 | 0.43 |
| ▸ | BRAF | P15056 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | SLC6A15 | Q9H2J7 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1127220 | 0.87 | NR1I2 (0.45) | NR1I2BRAF | |
| SCHEMBL1127227 | 0.85 | HRH1 (0.35) | NR1I2BRAFMAPK14HRH1SLC6A15 | |
| SCHEMBL1872195 | 0.85 | NR1I2 (0.48) | NR1I2BRAFEGFR | |
| SCHEMBL1127181 | 0.85 | NR1I2 (0.53) | NR1I2BRAF | |
| SCHEMBL1127440 | 0.85 | NR1I2 (0.44) | NR1I2BRAFLMNATP53MAPT | |
| SCHEMBL31111746 | 0.83 | NR1I2 (0.43) | NR1I2BRAF | |
| SCHEMBL1127251 | 0.83 | NR1I2 (0.49) | NR1I2BRAF | |
| SCHEMBL1127381 | 0.83 | NR1I2 (0.65) | NR1I2BRAF | |
| SCHEMBL1866858 | 0.80 | BRAF (0.46) | NR1I2BRAFLMNATP53MAPT | |
| SCHEMBL31111482 | 0.80 | NR1I2 (0.41) | NR1I2BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282636-A2 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GlaxoSmithKline LLC (US) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009137391-A2 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-11-12 | — | — | WO | disclosed |