Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30234731 | 1.00 | MAPT (0.42) | MAPTLMNAKDM4EHSD17B10TSHR | |
| SCHEMBL1989247 | 0.97 | MAPT (0.40) | MAPTLMNAKDM4EHSD17B10TSHR | |
| SCHEMBL1126434 | 0.91 | MAPT (0.39) | MAPTLMNAKDM4EHSD17B10TSHR | |
| SCHEMBL1127435 | 0.90 | MAPT (0.40) | MAPTLMNAKDM4EHSD17B10TSHR | |
| SCHEMBL1991472 | 0.90 | KCNH2 (0.44) | MAPTLMNAKDM4EHSD17B10TSHR | |
| SCHEMBL30235095 | 0.90 | KCNH2 (0.44) | MAPTLMNAKDM4EHSD17B10TSHR | |
| SCHEMBL1126732 | 0.90 | MAPT (0.38) | MAPTLMNAKDM4EHSD17B10TSHR | |
| SCHEMBL1126647 | 0.90 | MAPT (0.40) | MAPTLMNAKDM4EHSD17B10TSHR | |
| SCHEMBL1126552 | 0.90 | MAPT (0.39) | MAPTLMNAKDM4EHSD17B10TSHR | |
| SCHEMBL1126530 | 0.90 | MAPT (0.39) | MAPTLMNAKDM4EHSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9452168-B2 | Pyrrole antifungal agents | F2G LTD (GB) | 2016-09-27 | — | — | US | claimed |
| US-20150238500-A1 | PYRROLE ANTIFUNGAL AGENTS | F2G LTD (GB) | 2015-08-27 | — | — | US | claimed |
| US-8993574-B2 | Pyrrole antifungal agents | F2G LTD (GB) | 2015-03-31 | — | — | US | claimed |
| US-20110152285-A1 | PYRROLE ANTIFUNGAL AGENTS | F2G LTD (GB) | 2011-06-23 | — | — | US | claimed |
| US-11065228-B2 | Antifungal agents | F2G LIMITED (GB) | 2021-07-20 | — | — | US | disclosed |
| US-20200179340-A1 | ANTIFUNGAL AGENTS | F2G LTD (GB) | 2020-06-11 | — | — | US | disclosed |
| CN-111096967-A | Antifungal agent | F2G有限公司 | 2020-05-05 | — | — | CN | disclosed |
| US-10596150-B2 | Antifungal agents | F2G LIMITED (GB) | 2020-03-24 | — | — | US | disclosed |
| US-20190314333-A1 | ANTIFUNGAL AGENTS | F2G LTD (GB) | 2019-10-17 | — | — | US | disclosed |
| US-10201524-B2 | Antifungal agents | F2G LIMITED (GB) | 2019-02-12 | — | — | US | disclosed |
| EP-3415511-A1 | ANTIFUNGAL AGENTS | F2G Limited (GB) | 2018-12-19 | — | — | EP | disclosed |
| EP-3221308-B1 | ANTIFUNGAL AGENTS | F2G LTD (GB) | 2018-09-19 | — | — | EP | disclosed |
| EP-2283006-B1 | PYRROLE ANTIFUNGAL AGENTS | F2G LTD (GB) | 2015-02-25 | — | — | EP | disclosed |
| EP-2626361-B1 | Pyrrole antifungal agents | F2G LTD (GB) | 2014-10-15 | — | — | EP | disclosed |
| US-20130288956-A1 | COMBINED PHARMACEUTICAL COMPOSITION AS ANTIFUNGAL AGENT | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-10-31 | — | — | US | disclosed |
| EP-2636409-A1 | COMBINED PHARMACEUTICAL COMPOSITION AS ANTIFUNGAL AGENT | Eisai R&D Management Co., Ltd. (JP) | 2013-09-11 | — | — | EP | disclosed |
| EP-2626361-A1 | Pyrrole antifungal agents | F2G Limited (GB) | 2013-08-14 | — | — | EP | disclosed |
| US-20110152285-A1 | PYRROLE ANTIFUNGAL AGENTS | F2G LTD (GB) | 2011-06-23 | — | — | US | disclosed |
| EP-2283006-A1 | PYRROLE ANTIFUNGAL AGENTS | F2G Limited (GB) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009130481-A1 | PYRROLE ANTIFUNGAL AGENTS | F2G LTD (GB) | 2009-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130288956-A1 | COMBINED PHARMACEUTICAL COMPOSITION AS ANTIFUNGAL AGENT | DPM1, MTMR1, CHAMP1 | MAPT 670/4885LMNA 4033/4885KDM4E 993/4885 |
| US-20200179340-A1 | ANTIFUNGAL AGENTS | DPM1, AADAC, PIK3C3 | MAPT 3096/4885LMNA 4256/4885KDM4E 746/4885 |
| US-20110152285-A1 | PYRROLE ANTIFUNGAL AGENTS | FOXM1, PYCR1, ARG1 | MAPT 1696/4885LMNA 3641/4885KDM4E 1706/4885 |
| US-20150238500-A1 | PYRROLE ANTIFUNGAL AGENTS | FOXM1, PYCR1, ARG1 | MAPT 1696/4885LMNA 3641/4885KDM4E 1706/4885 |
| US-11065228-B2 | Antifungal agents | DPM1, AADAC, PIK3C3 | MAPT 3096/4885LMNA 4256/4885KDM4E 746/4885 |
| US-20190314333-A1 | ANTIFUNGAL AGENTS | DPM1, AADAC, PIK3C3 | MAPT 3096/4885LMNA 4256/4885KDM4E 746/4885 |
| US-10201524-B2 | Antifungal agents | DPM1, AADAC, PIK3C3 | MAPT 3096/4885LMNA 4256/4885KDM4E 746/4885 |
| US-10596150-B2 | Antifungal agents | DPM1, AADAC, PIK3C3 | MAPT 3096/4885LMNA 4256/4885KDM4E 746/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.