Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.50 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.49 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.49 |
| ▸ | F11 | P03951 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PTAFR | P25105 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11275415 | 0.89 | PDE3B (0.45) | POLBPDE3BPDE3AP2RY12F11 | |
| SCHEMBL11275661 | 0.89 | PDE3B (0.49) | POLBPDE3BPDE3AP2RY12LMNA | |
| SCHEMBL11266845 | 0.88 | PDE3B (0.62) | POLBPDE3BPDE3AP2RY12LMNA | |
| SCHEMBL11276115 | 0.87 | PDE3B (0.58) | POLBPDE3BPDE3AP2RY12LMNA | |
| SCHEMBL11270806 | 0.86 | PDE3B (0.47) | POLBPDE3BPDE3AP2RY12KCNH2 | |
| SCHEMBL11290690 | 0.86 | PDE3B (0.47) | POLBPDE3BPDE3AP2RY12LMNA | |
| SCHEMBL11275990 | 0.86 | F11 (0.48) | POLBPDE3BPDE3AP2RY12F11 | |
| SCHEMBL11274084 | 0.82 | PDE3B (0.52) | POLBPDE3BPDE3AP2RY12KCNH2 | |
| 1,4-Dichlorobenzene SCHEMBL11284601 | 0.82 | F11 (0.54) | POLBPDE3BPDE3AF11KCNH2 | |
| SCHEMBL11283835 | 0.82 | LMNA (0.44) | POLBPDE3BPDE3AP2RY12LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4329347-A | Cardiotonic and antithrombotic sulfur-containing derivatives of carbostyril | BOEHRINGER INGELHEIM GMBH (DE) | 1982-05-11 | — | — | US | disclosed |
| EP-0003771-A1 | Carbostyrile derivatives, their preparation and pharmaceutical compositions containing them | Dr. Karl Thomae GmbH (DE) | 1979-09-05 | — | — | EP | disclosed |