Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 4/20 | 0.44 |
| ▸ | BRAF | P15056 | 9/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 3/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1127439 | 0.90 | NR1I2 (0.46) | NR1I2BRAFMAPT | |
| SCHEMBL31111749 | 0.90 | NR1I2 (0.46) | NR1I2BRAFMAPT | |
| SCHEMBL1127352 | 0.87 | NR1I2 (0.33) | NR1I2BRAFCSNK1DCSNK1E | |
| SCHEMBL31111483 | 0.87 | NR1I2 (0.43) | NR1I2BRAFTP53MAPT | |
| SCHEMBL12349967 | 0.85 | NR1I2 (0.43) | NR1I2BRAFEGFR | |
| SCHEMBL1127223 | 0.85 | NR1I2 (0.43) | NR1I2BRAFLMNATP53MAPT | |
| SCHEMBL1127181 | 0.84 | NR1I2 (0.53) | NR1I2BRAF | |
| SCHEMBL1872195 | 0.84 | NR1I2 (0.48) | NR1I2BRAFEGFR | |
| SCHEMBL31111938 | 0.84 | NR1I2 (0.42) | NR1I2BRAF | |
| SCHEMBL31111630 | 0.82 | NR1I2 (0.41) | NR1I2BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282636-A2 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GlaxoSmithKline LLC (US) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009137391-A2 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-11-12 | — | — | WO | disclosed |