Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 8/20 | 0.60 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.60 |
| ▸ | CA1 | P00915 | 8/20 | 0.39 |
| ▸ | CA2 | P00918 | 8/20 | 0.39 |
| ▸ | ACHE | P22303 | 5/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11398494 | 0.83 | MTNR1A (0.52) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL11398493 | 0.76 | MTNR1A (0.51) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL1970413 | 0.76 | MTNR1A (1.00) | MTNR1AMTNR1BCA1CA2 | |
| SCHEMBL1970411 | 0.76 | MTNR1A (1.00) | MTNR1AMTNR1BCA1CA2 | |
| SCHEMBL11275699 | 0.76 | MTNR1A (0.66) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL11399968 | 0.74 | MTNR1A (0.62) | MTNR1AMTNR1BCA1CA2CA12 | |
| SCHEMBL9669811 | 0.71 | CA1 (0.72) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL20909871 | 0.71 | MTNR1A (0.68) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL3976285 | 0.71 | CA1 (0.72) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL12586121 | 0.71 | MTNR1A (0.68) | MTNR1AMTNR1BCA1CA2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014145512-A2 | POTENT SMALL MOLECULE INHIBITORS OF AUTOPHAGY, AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-09-18 | — | — | WO | disclosed |
| EP-0014792-B1 | TETRAHYDRO-2H-BENZO(C)PYRROLES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THE COMPOUNDS FOR USE AS THERAPEUTICALS | ELI LILLY AND COMPANY (US) | 1982-12-01 | — | — | EP | disclosed |
| US-4264622-A | TREATMENT OF PARKINSON*S DISEASE | ELI LILLY AND COMPANY (US) | 1981-04-28 | — | — | US | disclosed |
| US-4235776-A | USED FOR TREATMENT OF PARKINSON'S DISEASE, PROLACTIN INHIBITORS, AND DOPAMINE AGONISTS | ELI LILLY AND COMPANY (US) | 1980-11-25 | — | — | US | disclosed |
| EP-0014792-A1 | Tetrahydro-2H-benzo(c)pyrroles, their preparation, pharmaceutical compositions containing them and the compounds for use as therapeuticals | ELI LILLY AND COMPANY (US) | 1980-09-03 | — | — | EP | disclosed |