Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 9/20 | 0.66 |
| ▸ | MTNR1B | P49286 | 8/20 | 0.66 |
| ▸ | CA1 | P00915 | 5/20 | 0.41 |
| ▸ | CA2 | P00918 | 5/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA7 | P43166 | 2/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1970411 | 0.79 | MTNR1A (1.00) | MTNR1AMTNR1BCA1CA2 | |
| SCHEMBL1970413 | 0.79 | MTNR1A (1.00) | MTNR1AMTNR1BCA1CA2 | |
| SCHEMBL11211906 | 0.76 | MTNR1A (0.54) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL11273733 | 0.76 | MTNR1A (0.60) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL9669811 | 0.74 | CA1 (0.72) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL12586121 | 0.74 | MTNR1A (0.68) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL3976285 | 0.74 | CA1 (0.72) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL20909871 | 0.74 | MTNR1A (0.68) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL11240523 | 0.73 | MTNR1A (0.54) | MTNR1AMTNR1B | |
| SCHEMBL11243423 | 0.73 | MTNR1A (0.54) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0014792-B1 | TETRAHYDRO-2H-BENZO(C)PYRROLES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THE COMPOUNDS FOR USE AS THERAPEUTICALS | ELI LILLY AND COMPANY (US) | 1982-12-01 | — | — | EP | disclosed |
| US-4264622-A | TREATMENT OF PARKINSON*S DISEASE | ELI LILLY AND COMPANY (US) | 1981-04-28 | — | — | US | disclosed |
| US-4235776-A | USED FOR TREATMENT OF PARKINSON'S DISEASE, PROLACTIN INHIBITORS, AND DOPAMINE AGONISTS | ELI LILLY AND COMPANY (US) | 1980-11-25 | — | — | US | disclosed |
| EP-0014792-A1 | Tetrahydro-2H-benzo(c)pyrroles, their preparation, pharmaceutical compositions containing them and the compounds for use as therapeuticals | ELI LILLY AND COMPANY (US) | 1980-09-03 | — | — | EP | disclosed |