Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 11/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.38 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.38 |
| ▸ | MEP1B | Q16820 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11278306 | 1.00 | CD274 (0.40) | CD274PDCD1NR4A2KDM4EALDH1A1 | |
| SCHEMBL29141118 | 0.89 | CD274 (0.44) | CD274PDCD1NR4A2KDM4EMEP1B | |
| SCHEMBL30170212 | 0.89 | CD274 (0.44) | CD274PDCD1NR4A2KDM4EMEP1B | |
| SCHEMBL11394474 | 0.84 | ALDH1A1 (0.41) | CD274PDCD1KDM4EALDH1A1HPGD | |
| SCHEMBL11402492 | 0.84 | ALDH1A1 (0.41) | CD274PDCD1KDM4EALDH1A1HPGD | |
| SCHEMBL11564824 | 0.81 | MEN1 (0.44) | KDM4EALDH1A1HPGDMEP1BL3MBTL1 | |
| SCHEMBL20957060 | 0.79 | CYP1A2 (0.47) | KDM4EALDH1A1HPGDHTTL3MBTL1 | |
| SCHEMBL11285599 | 0.79 | KDM4E (0.45) | CD274PDCD1NR4A2KDM4EALDH1A1 | |
| SCHEMBL8601665 | 0.76 | CD44 (0.41) | KDM4EALDH1A1HPGDHTTL3MBTL1 | |
| SCHEMBL7139605 | 0.74 | KDM4E (0.60) | CD274NR4A2KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0000718-B1 | QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL PREPARATIONS AND THEIR PREPARATION | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-03-24 | — | — | EP | disclosed |