SCHEMBL8601665

SCHEMBL8601665

Cc1cccc(N)c1CC(C(=O)O)C(=O)O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CD44 P16070 1/20 0.41
ALDH1A1 P00352 3/20 0.39
L3MBTL1 Q9Y468 2/20 0.39
HTT P42858 1/20 0.39
ATP4A P20648 1/20 0.39
ATP4B P51164 1/20 0.39
PPARG P37231 1/20 0.38
PPARA Q07869 1/20 0.38
CYP3A4 P08684 2/20 0.38
TDP1 Q9NUW8 2/20 0.38
CYP2C19 P33261 1/20 0.37
KDM4E B2RXH2 3/20 0.36
HPGD P15428 2/20 0.36
MYC P01106 1/20 0.36
KMT2A Q03164 1/20 0.36
LDHA P00338 1/20 0.36
TSHR P16473 1/20 0.35
PIK3CA P42336 1/20 0.35
ESR1 P03372 1/20 0.35
KCNH2 Q12809 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6338911 0.79 CD44 (0.45) CD44ALDH1A1L3MBTL1HTTATP4A
SCHEMBL28474465 0.79 KDM4E (0.51) CD44ALDH1A1CYP3A4TDP1CYP2C19
SCHEMBL3722266 0.79 AKR1B1 (0.48) ALDH1A1CYP3A4CYP2C19KDM4EKMT2A
SCHEMBL27876812 0.78 CD44 (0.43) CD44ALDH1A1L3MBTL1HTTATP4A
SCHEMBL8020749 0.77 ALDH1A1 (0.39) CD44ALDH1A1L3MBTL1HTTATP4A
SCHEMBL7315180 0.77 ESR1 (0.39) CD44ALDH1A1L3MBTL1HTTTDP1
SCHEMBL11278306 0.76 CD274 (0.40) ALDH1A1L3MBTL1HTTKDM4EHPGD
SCHEMBL11273899 0.76 CD274 (0.40) ALDH1A1L3MBTL1HTTKDM4EHPGD
SCHEMBL20957060 0.75 CYP1A2 (0.47) CD44ALDH1A1L3MBTL1HTTCYP3A4
SCHEMBL10579910 0.75 CD44 (0.41) CD44ALDH1A1L3MBTL1HTTATP4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0823927-A2 INK COMPOSITION ZENECA LIMITED (GB) 1998-02-18 EP disclosed
WO-1996034916-A2 INK COMPOSITION ZENECA LIMITED (GB) 1996-11-07 WO disclosed