Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 1/20 | 0.42 |
| ▸ | COMT | P21964 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL942110 | 0.89 | TRPA1 (0.50) | MPLCOMTTRPA1AURKAAURKB | |
| SCHEMBL11279293 | 0.88 | CYP2D6 (0.41) | MPLCOMTTRPA1NOTUMSMN1; SMN2 | |
| SCHEMBL17272412 | 0.87 | TRPA1 (0.48) | MPLCOMTTRPA1AURKAAURKB | |
| Ammonia Solution, Strong SCHEMBL17272173 | 0.87 | TRPA1 (0.48) | MPLCOMTTRPA1AURKAAURKB | |
| SCHEMBL17272460 | 0.87 | TRPA1 (0.48) | MPLCOMTTRPA1AURKAAURKB | |
| Water SCHEMBL11269395 | 0.87 | TRPA1 (0.48) | MPLCOMTTRPA1AURKAAURKB | |
| SCHEMBL17272202 | 0.87 | TRPA1 (0.48) | MPLCOMTTRPA1AURKAAURKB | |
| Ammonia Solution, Strong SCHEMBL17272172 | 0.87 | TRPA1 (0.48) | MPLCOMTTRPA1AURKAAURKB | |
| SCHEMBL23803135 | 0.85 | TRPA1 (0.46) | MPLCOMTTRPA1AURKAAURKB | |
| SCHEMBL29664035 | 0.85 | TRPA1 (0.46) | MPLCOMTTRPA1AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0029990-B1 | BIPHENYLMETHANE DERIVATIVE, METHODS FOR ITS PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1982-09-08 | — | — | EP | disclosed |
| EP-0029990-A1 | Biphenylmethane derivative, methods for its production and pharmaceutical compositions containing it | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1981-06-10 | — | — | EP | disclosed |