SCHEMBL11274355

SCHEMBL11274355

c1ccc(CCC(CCc2ccccc2)Cn2ccnc2)cc1

nearest known ligand 0.71

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 2/20 0.57
CYP1A2 P05177 1/20 0.57
POLB P06746 1/20 0.57
CYP3A4 P08684 1/20 0.57
CYP2D6 P10635 1/20 0.57
MAPT P10636 1/20 0.57
CYP11B1 P15538 1/20 0.57
CYP11B2 P19099 1/20 0.57
TBXAS1 P24557 1/20 0.57
QPCT Q16769 1/20 0.57
CYP4Z1 Q86W10 1/20 0.57
QPCTL Q9NXS2 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11281773 0.94 CYP19A1 (0.51) CYP19A1CYP1A2POLBCYP3A4CYP2D6
SCHEMBL11304071 0.92 CYP19A1 (0.53) CYP19A1CYP1A2POLBCYP3A4CYP2D6
SCHEMBL11272141 0.92 CYP1A2 (0.60) CYP19A1CYP1A2POLBCYP3A4CYP2D6
SCHEMBL11275481 0.92 CYP19A1 (0.54) CYP19A1CYP1A2POLBCYP3A4CYP2D6
Hydrochloric Acid SCHEMBL11273552 0.90 CYP1A2 (0.59) CYP19A1CYP1A2POLBCYP3A4CYP2D6
SCHEMBL11278579 0.89 CYP1A2 (0.52) CYP19A1CYP1A2POLBCYP3A4CYP2D6
SCHEMBL11276740 0.89 CYP11B1 (0.56) CYP19A1CYP1A2POLBCYP3A4CYP2D6
SCHEMBL11278157 0.88 ALDH1A1 (0.57) CYP19A1CYP1A2CYP3A4MAPTTBXAS1
SCHEMBL11273998 0.87 CYP19A1 (0.49) CYP19A1CYP1A2POLBCYP3A4CYP2D6
SCHEMBL11288822 0.87 CYP1A2 (0.56) CYP19A1CYP1A2POLBCYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0064244-A1 Spermicidal 1-bis(arylalkyl)alkylimidazoles SYNTEX (U.S.A.) INC. (US) 1982-11-10 EP disclosed