SCHEMBL11275223

SCHEMBL11275223

O=C(O)[C@@]1(Cc2ccccc2)OC[C@@H](CO)O1

nearest known ligand 0.39

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 3/20 0.39
TMEM97 Q5BJF2 2/20 0.39
HSD11B1 P28845 1/20 0.35
CYP3A4 P08684 1/20 0.35
HTR1A P08908 2/20 0.34
MGLL Q99685 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9326347 0.78 SIGMAR1 (0.40) SIGMAR1TMEM97HTR1A
Acetic Acid SCHEMBL15956069 0.78 SIGMAR1 (0.44) SIGMAR1TMEM97HSD11B1CYP3A4HTR1A
Propionic Acid SCHEMBL15955794 0.75 TMEM97 (0.41) SIGMAR1TMEM97HSD11B1CYP3A4HTR1A
SCHEMBL15955853 0.74 TMEM97 (0.41) SIGMAR1TMEM97CYP3A4
SCHEMBL10487154 0.74 MAOA (0.39) HSD11B1CYP3A4
SCHEMBL5665989 0.74 MAOA (0.39) HSD11B1CYP3A4
Butyric Acid SCHEMBL15955929 0.72 MEN1 (0.40) SIGMAR1TMEM97HSD11B1CYP3A4
3-Methylbutanoic Acid SCHEMBL15956110 0.71 TMEM97 (0.39) SIGMAR1TMEM97HSD11B1CYP3A4
Valeric Acid SCHEMBL15956332 0.71 TMEM97 (0.38) SIGMAR1TMEM97CYP3A4
Benzyl Alcohol SCHEMBL16651422 0.70 SIGMAR1 (0.52) SIGMAR1TMEM97CYP3A4HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0046488-A2 Substituted 2,5,7-trioxa-bicyclo(2.2.2)octan-6-ones, 3,6,8-trioxa-bicyclo(3.2.1)octan-4-ones and 1,3-dioxane-carboxylic acid and 1,3-dioxolane-2-carboxylic acid compounds, and their preparation HÜLS TROISDORF AKTIENGESELLSCHAFT (DE) 1982-03-03 EP disclosed