Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.47 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30365137 | 0.93 | MAPT (0.54) | MAPTTDP1KMT2APOLBATM | |
| SCHEMBL10708407 | 0.87 | MAPT (0.64) | MAPTTDP1KMT2APOLBATM | |
| SCHEMBL10708396 | 0.87 | MAPT (0.64) | MAPTTDP1KMT2APOLBATM | |
| SCHEMBL11647906 | 0.83 | MAPT (0.53) | MAPTTDP1KMT2APOLBATM | |
| SCHEMBL11648839 | 0.83 | MAPT (0.55) | MAPTTDP1KMT2APOLBATM | |
| SCHEMBL11648184 | 0.82 | MAPT (0.54) | MAPTTDP1KMT2APOLBATM | |
| SCHEMBL9031160 | 0.75 | BACE1 (0.50) | MAPTTDP1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL9031155 | 0.75 | BACE1 (0.50) | MAPTTDP1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL10750848 | 0.74 | ALDH1A1 (0.48) | MAPTTDP1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL16474213 | 0.74 | MAPT (0.44) | MAPTTDP1KMT2APOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0052959-A1 | Production of purine derivatives and intermediates therefor | Takeda Chemical Industries, Ltd. (JP) | 1982-06-02 | — | — | EP | disclosed |
| US-4083841-A | FOLIC ACID ANTAGONISTS | SHAW UNIVERSITY (US) | 1978-04-11 | — | — | US | disclosed |