SCHEMBL11276235

SCHEMBL11276235

CN1CCC[C@H]1c1cccnc1CCc1ccccc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 4/20 0.47
CHRNB4 P30926 4/20 0.47
CHRNA3 P32297 4/20 0.47
CHRNA7 P36544 3/20 0.47
CHRNA4 P43681 3/20 0.47
ADRA1A P35348 1/20 0.46
HRH1 P35367 1/20 0.46
ADRA1B P35368 1/20 0.46
CHRNB1 P11230 2/20 0.44
CHRNB3 Q05901 2/20 0.44
JAK2 O60674 1/20 0.44
ALDH1A1 P00352 2/20 0.44
CHRNA2 Q15822 2/20 0.44
LMNA P02545 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
HTR3E A5X5Y0 1/20 0.44
PSIP1 O75475 1/20 0.44
TRPA1 O75762 1/20 0.44
HTR3B O95264 1/20 0.44
CHRNA1 P02708 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11276237 1.00 CHRNB2 (0.47) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL156222 0.85 CHRNB2 (0.47) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL9385174 0.82 CHRNB2 (0.49) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL11273849 0.82 CHRNB2 (0.49) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL16787379 0.82 CHRNB2 (0.47) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL2682571 0.81 CHRNB2 (0.48) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL524484 0.81 CHRNB2 (0.48) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL1533666 0.81 CHRNB2 (0.48) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
Water SCHEMBL1333404 0.77 CHRNB2 (0.42) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL10472774 0.76 CHRNB2 (0.51) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0000106-B1 2-ALKYL NICOTINOIDS AND PROCESSES FOR THEIR PRODUCTION AND USE PHILIP MORRIS INCORPORATED (US) 1982-02-17 EP disclosed
US-4220781-A QUARTINIZATION, REARRANGEMENT AND REDUCTION PHILIP MORRIS, INC. (US) 1980-09-02 US disclosed
US-4155909-A INSECTICIDES PHILIP MORRIS INCORPORATED (US) 1979-05-22 US disclosed
EP-0000106-A1 2-Alkyl nicotinoids and processes for their production and use PHILIP MORRIS INCORPORATED (US) 1978-12-20 EP disclosed