SCHEMBL9385174

SCHEMBL9385174

CCc1ncccc1[C@@H]1CCCN1C

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 5/20 0.49
CHRNA4 P43681 5/20 0.49
CHRNA7 P36544 4/20 0.49
CHRNB4 P30926 3/20 0.49
CHRNA3 P32297 3/20 0.49
ALDH1A1 P00352 2/20 0.49
CHRNA2 Q15822 2/20 0.49
LMNA P02545 1/20 0.49
TDP1 Q9NUW8 1/20 0.49
HTR3E A5X5Y0 1/20 0.49
PSIP1 O75475 1/20 0.49
TRPA1 O75762 1/20 0.49
HTR3B O95264 1/20 0.49
CHRNA1 P02708 1/20 0.49
CHRNG P07510 1/20 0.49
MAPT P10636 1/20 0.49
CHRNB1 P11230 1/20 0.49
CYP2A6 P11509 1/20 0.49
PTGS1 P23219 1/20 0.49
CHRNA5 P30532 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11273849 1.00 CHRNB2 (0.49) CHRNB2CHRNA4CHRNA7CHRNB4CHRNA3
SCHEMBL156222 0.89 CHRNB2 (0.47) CHRNB2CHRNA4CHRNA7CHRNB4CHRNA3
SCHEMBL524484 0.87 CHRNB2 (0.48) CHRNB2CHRNA4CHRNA7CHRNB4CHRNA3
SCHEMBL2682571 0.87 CHRNB2 (0.48) CHRNB2CHRNA4CHRNA7CHRNB4CHRNA3
SCHEMBL1533666 0.87 CHRNB2 (0.48) CHRNB2CHRNA4CHRNA7CHRNB4CHRNA3
SCHEMBL11276237 0.82 CHRNB2 (0.47) CHRNB2CHRNA4CHRNA7CHRNB4CHRNA3
SCHEMBL11276235 0.82 CHRNB2 (0.47) CHRNB2CHRNA4CHRNA7CHRNB4CHRNA3
SCHEMBL16787379 0.82 CHRNB2 (0.47) CHRNB2CHRNA4CHRNA7CHRNB4CHRNA3
SCHEMBL9298373 0.80 CHRNB2 (0.42) CHRNB2CHRNA4CHRNA7CHRNB4CHRNA3
SCHEMBL30866537 0.80 CHRNB2 (0.53) CHRNB2CHRNA4CHRNA7CHRNB4CHRNA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1994004152-A1 NICOTINE DERIVATIVES THAT ENHANCE COGNITIVE FUNCTION ABBOTT LABORATORIES (US) 1994-03-03 WO disclosed
EP-0000106-B1 2-ALKYL NICOTINOIDS AND PROCESSES FOR THEIR PRODUCTION AND USE PHILIP MORRIS INCORPORATED (US) 1982-02-17 EP disclosed
US-4220781-A QUARTINIZATION, REARRANGEMENT AND REDUCTION PHILIP MORRIS, INC. (US) 1980-09-02 US disclosed
US-4155909-A INSECTICIDES PHILIP MORRIS INCORPORATED (US) 1979-05-22 US disclosed
EP-0000106-A1 2-Alkyl nicotinoids and processes for their production and use PHILIP MORRIS INCORPORATED (US) 1978-12-20 EP disclosed