Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 9/20 | 0.51 |
| ▸ | GABRB3 | P28472 | 9/20 | 0.51 |
| ▸ | GABRA5 | P31644 | 9/20 | 0.51 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | PKM | P14618 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.43 |
| ▸ | RELA | Q04206 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7908815 | 0.81 | GABRG2 (0.42) | GABRG2GABRB3GABRA5NPC1RAB9A | |
| SCHEMBL9262640 | 0.73 | GABRG2 (0.50) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL9266623 | 0.72 | GABRG2 (0.44) | GABRG2GABRB3GABRA5RAB9ASMN1; SMN2 | |
| SCHEMBL7921869 | 0.71 | RXFP1 (0.35) | GABRG2GABRB3GABRA5NPC1RAB9A | |
| SCHEMBL7136243 | 0.69 | CES1 (0.47) | GABRG2GABRB3GABRA5MAPTPKM | |
| SCHEMBL1683061 | 0.69 | HRH1 (0.48) | GABRG2GABRB3GABRA5NPC1RAB9A | |
| SCHEMBL16897447 | 0.69 | KCNJ1 (0.55) | NPC1RAB9ASMN1; SMN2TP53POLB | |
| SCHEMBL2426577 | 0.69 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL2402138 | 0.69 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL1375888 | 0.68 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA1GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4313950-A | Antireproductive tricyclic ortho-fused nitrogen containing compounds | GRUPPO LEPETIT S.P.A. (IT) | 1982-02-02 | — | — | US | disclosed |
| US-4275066-A | 1,2,4-TRIAZOLO(5.1A)ISOINDOZE, TRIAZOLO(5.1A) ISOQUINOLINE OR 1,2,4,-TRIAZOLO (5.1A)(2) BENZAZEPINE CONTRACEPTIVES | GRUPPO LEPETIT S.P.A. (IT) | 1981-06-23 | — | — | US | disclosed |
| US-4007276-A | ANTIFERTILITY, ANTIINFLAMMATORY, ANALGESIC, CNS DEPRESSANT, MICROBIOCIDES | GRUPPO LEPETIT, S.P.A. (IT) | 1977-02-08 | — | — | US | disclosed |