Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 2/20 | 0.47 |
| ▸ | MIF | P14174 | 3/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7908815 | 0.87 | GABRG2 (0.42) | CES1ALDH1A1KDM4EPKMGABRG2 | |
| SCHEMBL7136275 | 0.80 | GABRG2 (0.41) | GABRG2GABRB3GABRA5 | |
| SCHEMBL7136428 | 0.80 | GABRG2 (0.38) | CYP19A1CYP11B2GABRG2GABRB3GABRA5 | |
| SCHEMBL7136207 | 0.76 | SETD7 (0.59) | MAOAACHEALDH1A1MAOBMAPK1 | |
| SCHEMBL7138437 | 0.72 | CES1 (0.47) | CES1MIFMAOAACHETDP1 | |
| SCHEMBL14997105 | 0.70 | GABRG2 (0.34) | MAOATDP1L3MBTL1ALDH1A1MAOB | |
| SCHEMBL7136762 | 0.70 | HRH1 (0.64) | L3MBTL1ALDH1A1MAPK1MAPTALOX15 | |
| SCHEMBL11277543 | 0.69 | GABRG2 (0.51) | ALDH1A1KDM4EPKMGABRG2GABRB3 | |
| SCHEMBL7136916 | 0.69 | SETD7 (0.38) | — | |
| SCHEMBL7143476 | 0.69 | CES1 (0.47) | CES1MIFMAOAACHETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675887-B1 | ANTIALLERGIC TRIAZOLOBENZAZEPINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2003-04-02 | — | — | EP | disclosed |
| EP-0675887-A1 | ANTIALLERGIC TRIAZOLOBENZAZEPINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-10-11 | — | — | EP | disclosed |
| WO-1994013671-A1 | ANTIALLERGIC TRIAZOLOBENZAZEPINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-06-23 | — | — | WO | disclosed |